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    Sod1 superoxide dismutase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24786, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sod1provided by RGD
    Official Full Name
    superoxide dismutase 1provided by RGD
    Primary source
    RGD:3731
    See related
    EnsemblRapid:ENSRNOG00000002115 AllianceGenome:RGD:3731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CuZnSOD
    Summary
    Enables copper ion binding activity; protein phosphatase 2B binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; removal of superoxide radicals; and response to antipsychotic drug. Located in several cellular components, including dense core granule; neuronal cell body; and peroxisome. Part of protein-containing complex. Used to study hyperthyroidism; hypothyroidism; middle cerebral artery infarction; and sciatic neuropathy. Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); congenital diaphragmatic hernia; metabolic dysfunction-associated steatohepatitis; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 6403.9), Kidney (RPKM 4173.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sod1 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (42942742..42948399)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (29456673..29462249)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (30363282..30368858)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene TIAM Rac1 associated GEF 1 Neighboring gene uncharacterized LOC102552925 Neighboring gene uncharacterized LOC134480968 Neighboring gene SR-related CTD-associated factor 4 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables copper ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables copper ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2B binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase 2B binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2B binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables superoxide dismutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables superoxide dismutase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables superoxide dismutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables superoxide dismutase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within action potential initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anterograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within auditory receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in auditory receptor cell stereocilium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to ATP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to potassium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of ectopic germ cell programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryo implantation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryo implantation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hydrogen peroxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hydrogen peroxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hydrogen peroxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle cell cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within myeloid cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myeloid cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of developmental process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of reproductive process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neurofilament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurofilament cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within peripheral nervous system myelin maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peripheral nervous system myelin maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of multicellular organism growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within relaxation of vascular associated smooth muscle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in relaxation of vascular associated smooth muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in removal of superoxide radicals IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in removal of superoxide radicals IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in removal of superoxide radicals ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in removal of superoxide radicals TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to antipsychotic drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to axon injury ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to axon injury ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to carbon monoxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to copper ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ethanol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to superoxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to superoxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to superoxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retina homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retina homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of sound ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in superoxide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in superoxide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in superoxide metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmission of nerve impulse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    superoxide dismutase [Cu-Zn]
    Names
    superoxide dismutase 1, soluble
    NP_058746.1
    XP_063126359.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017050.1NP_058746.1  superoxide dismutase [Cu-Zn]

      See identical proteins and their annotated locations for NP_058746.1

      Status: PROVISIONAL

      Source sequence(s)
      Y00404
      UniProtKB/Swiss-Prot
      P07632
      UniProtKB/TrEMBL
      A6JLB7, Q6LDS4
      Related
      ENSRNOP00000002885.6, ENSRNOT00000002885.8
      Conserved Domains (1) summary
      cd00305
      Location:3147
      Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      42942742..42948399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270289.1XP_063126359.1  superoxide dismutase [Cu-Zn] isoform X1