Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnmb4provided by RGD
Official Full Name: potassium calcium-activated channel subfamily M regulatory beta subunit 4provided by RGD
Primary source: RGD:620728
See related: EnsemblRapid:ENSRNOG00000054458 AllianceGenome:RGD:620728
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNMB4 (potassium calcium-activated channel subfamily M regulatory beta subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 95.9), Thymus (RPKM 24.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (53952150..54005101, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (52066145..52119098, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (59461808..59514759, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex Afferent Neuroexcitation via Negative Regulation on KCNMB4 and KCa1.1 beta4-subunit Expression.
Title: Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex Afferent Neuroexcitation via Negative Regulation on KCNMB4 and KCa1.1 β4-subunit Expression.
Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors.
Title: Upregulation of Beta4 subunit of BK(Ca) channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors.
The results demonstrate a modification in the mitochondrial BKCa channel gating properties in membrane preparations coming from a streptozotocin model of diabetic rats, an effect potentially linked to a change in BKCa beta4 and alpha subunits expression.
Title: Impairment of brain mitochondrial charybdotoxin- and ATP-insensitive BK channel activities in diabetes.
Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability
Title: An endoplasmic reticulum trafficking signal regulates surface expression of β4 subunit of a voltage- and Ca²⁺-activated K⁺ channel.
BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining poassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function.
Title: Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytes.
These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels.
Title: Modulation by the BK accessory β4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons.
There is interaction between the mtBK and the mitochondrial permeability transition pore (PTP) in a way that an open mtBK keeps the PTP closed.
Title: Hypoxia increases activity of the BK-channel in the inner mitochondrial membrane and reduces activity of the permeability transition pore.
beta4 subunit is a regulatory component of mitochondrial conductance Ca(2+)-activated potassium channels channels in neurons
Title: Differential distribution of Ca2+-activated potassium channel beta4 subunit in rat brain: immunolocalization in neuronal mitochondria.
There is a selective distribution of auxiliary beta1 subunits to the somatic and dendritic compartments and beta4 subunits to the terminal compartment of neurons in the hypothalamic-neurohypophysial system.
Title: Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system.
DiBAC(4)(3) activated whole-cell BKalphabeta1 and BKalphabeta4 currents in the same concentration range but partially blocked BKalphabeta2 currents. Structure activity relationships are discussed.
Title: Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493092

RH144266 (e-PCR)
- UniSTS:233511

AU048198 (e-PCR)
- UniSTS:109774

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium-activated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	ISO Inferred from Sequence Orthology more info
involved_in action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium-activated potassium channel subunit beta-4

Names: BK channel subunit beta-4; BKbeta4; calcium activated potassium channel beta 4 subunit; calcium-activated potassium channel, subfamily M subunit beta-4; charybdotoxin receptor subunit beta-4; k(VCA)beta-4; maxi K channel subunit beta-4; potassium channel subfamily M regulatory beta subunit 4; potassium large conductance calcium-activated channel, subfamily M, beta member 4; slo-beta-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023960.2 → NP_076450.1 calcium-activated potassium channel subunit beta-4

See identical proteins and their annotated locations for NP_076450.1

Status: PROVISIONAL

Source sequence(s)

AY028605

UniProtKB/Swiss-Prot

Q9ESK8

UniProtKB/TrEMBL

B1WBP1

Related

ENSRNOP00000075448.1, ENSRNOT00000085579.3

Conserved Domains (1) summary

pfam03185
Location:8 → 203

CaKB; Calcium-activated potassium channel, beta subunit