Ucp1 uncoupling protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ucp1provided by RGD
Full Name: uncoupling protein 1provided by RGD
Primary source: RGD:3931
See related: EnsemblRapid:ENSRNOG00000003580 AllianceGenome:RGD:3931
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ucp; Ucpa; Uncp
Summary: Enables GDP binding activity; GTP binding activity; and oxidative phosphorylation uncoupler activity. Involved in several processes, including cellular response to dehydroepiandrosterone; cellular response to fatty acid; and proton transmembrane transport. Located in mitochondrion. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 1730.7), Adrenal (RPKM 1679.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (41713350..41721421, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (24808782..24816853, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (24456976..24464808)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rats lacking Ucp1 present a novel translational tool for the investigation of thermogenic adaptation during cold challenge.
Title: Rats lacking Ucp1 present a novel translational tool for the investigation of thermogenic adaptation during cold challenge.
NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue.
Title: NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue.
Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring.
Title: Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring.
Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant.
Title: Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant.
Instead of UCP1-mediated mitochondrial uncoupling, cold acclimation increased the capacity of Sc Ing adipocytes to export fatty acids.
Title: Cold acclimation enhances UCP1 content, lipolysis, and triacylglycerol resynthesis, but not mitochondrial uncoupling and fat oxidation, in rat white adipocytes.
The expression of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) and uncoupling protein (UCP)-1 in brown adipocytes.
Title: Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.
e found that CPT1AM-expressing rBA have increased FAO, lipolysis, UCP1 protein levels and mitochondrial activity. Additionally, enhanced FAO reduced the palmitate-induced increase in triglyceride content and the expression of obese and inflammatory markers. Thus, CPT1AM-expressing rBA had enhanced fat-burning capacity and improved lipid-induced derangements.
Title: Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes.
The history of discovery of UCP1, the mitochondrial uncoupling protein of brown adipocyte, has been described. (Review)
Title: UCP1, the mitochondrial uncoupling protein of brown adipocyte: A personal contribution and a historical perspective.
In the absence of regulators (fatty acids, retinoids), rodent UCP1 presents a high ohmic proton conductance that cannot be detected in human UCP1.
Title: The distinct bioenergetic properties of the human UCP1.
Data indicate that prolonged cold exposure may induce anti-inflammatory response in mesenteric white adipose tissue associated with induction of UCP-1 expression.
Title: Continuous cold exposure induces an anti-inflammatory response in mesenteric adipose tissue associated with catecholamine production and thermogenin expression in rats.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94828 (e-PCR)
- UniSTS:120074

d19arb8 (e-PCR)
- UniSTS:121356

D19Mit9 (e-PCR), detects polymorphism
- UniSTS:119350

AI385626 (e-PCR)
- UniSTS:179772

RH94640 (e-PCR)
- UniSTS:119887

Ucp1 (e-PCR), detects polymorphism
- UniSTS:144726

D19Wox8 (e-PCR)
- UniSTS:119226

RH94528 (e-PCR)
- UniSTS:119776

D19Mit9 (e-PCR), detects polymorphism
- UniSTS:240375

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables cardiolipin binding	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidative phosphorylation uncoupler activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidative phosphorylation uncoupler activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidative phosphorylation uncoupler activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine ribonucleotide binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in adaptive thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cold	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dehydroepiandrosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in generation of precursor metabolites and energy	TAS Traceable Author Statement more info	PubMed
involved_in mitochondrial transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to temperature stimulus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial envelope	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial brown fat uncoupling protein 1

Names: UCP 1; mitochondrial brown fat uncoupling protein 1-like; solute carrier family 25 member 7; thermogenin; uncoupling protein 1 (mitochondrial, proton carrier)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.