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    Myh1 myosin heavy chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287408, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Myh1provided by RGD
    Official Full Name
    myosin heavy chain 1provided by RGD
    Primary source
    RGD:735061
    See related
    EnsemblRapid:ENSRNOG00000083924 AllianceGenome:RGD:735061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MYHC
    Summary
    Predicted to enable ATP hydrolysis activity and microfilament motor activity. Involved in muscle contraction. Part of muscle myosin complex. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 38815.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myh1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52384810..52408698)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (51885913..51909699)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53740841..53764610)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480700 Neighboring gene myosin heavy chain 2 Neighboring gene uncharacterized LOC102555216 Neighboring gene myosin heavy chain 4 Neighboring gene myosin heavy chain 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat liver fat-storing cell lines express sarcomeric myosin heavy chain mRNA and protein. Ogata I, et al. Cell Motil Cytoskeleton, 1993. PMID 8287498
    2. Transcript-specific mRNA trafficking based on the distribution of coexpressed myosin isoforms. Shoemaker SD, et al. Cells Tissues Organs, 1999. PMID 10460968
    3. Regulation of naturally occurring antisense RNA of myosin heavy chain (MyHC) in neonatal cardiomyocytes. Luther HP, et al. J Cell Biochem, 2005 Mar 1. PMID 15578571
    4. Effects of clenbuterol and cyclosporin A on the myosin heavy chain mRNA level and the muscle mass in rat masseter. Arai C, et al. J Physiol Sci, 2006 Jun. PMID 16839454
    5. IIx myosin heavy chain promoter regulation cannot be characterized in vivo by direct gene transfer. Pandorf CE, et al. Am J Physiol Cell Physiol, 2007 Oct. PMID 17670891

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plantar Mechanical Stimulation Maintains Slow Myosin Expression in Disused Rat Soleus Muscle via NO-Dependent Signaling.
      Title: Plantar Mechanical Stimulation Maintains Slow Myosin Expression in Disused Rat Soleus Muscle via NO-Dependent Signaling.
    2. The relative amount of type I MyHC isoform is increased in spontaneously hypertensive rats (SHR) compared to the Wistar-Kyoto strain.
      Title: Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
    3. IFN-gamma increased both proteasome and immunoproteasome activity in cardiac myocytes and their inhibition blocked myosin heavy chain loss and myocyte atrophy.
      Title: Interferon-γ causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis.
    4. MyHC1 levels were not different on immunoblots of the soleus of streptozocin-treated and control rats.
      Title: The slow sarco/endoplasmic reticulum Ca2+ -ATPase declines independently of slow myosin in soleus muscle of diabetic rats.
    5. Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.
      Title: Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.
    6. Results obtained with IIx MHC promoter-reporters show that the loss of the native chromatin environment and other cis elements may preclude use of the gene transfer approach, suggesting that there are hidden layers of regulation for this gene.
      Title: IIx myosin heavy chain promoter regulation cannot be characterized in vivo by direct gene transfer.
    7. Both clenbuterol and cyclosporin A treatment significantly decreased the MHC I mRNA level in the rat masseter muscle.
      Title: Effects of clenbuterol and cyclosporin A on the myosin heavy chain mRNA level and the muscle mass in rat masseter.
    8. Results indicate a coregulation of sense and antisense MyHC RNA under stimulation of T3 and phenylephrine in neonatal cardiomyocytes
      Title: Regulation of naturally occurring antisense RNA of myosin heavy chain (MyHC) in neonatal cardiomyocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in striated muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of muscle myosin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of muscle myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin, heavy polypeptide 1, skeletal muscle, adult
    Names
    myosin, heavy chain 1, skeletal muscle, adult
    type 2X myosin heavy chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135158.1 → NP_001128630.1  myosin, heavy polypeptide 1, skeletal muscle, adult

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LRV9
      Related
      ENSRNOP00000004295.7, ENSRNOT00000004295.8
      Conserved Domains (3) summary
      cd14910
      Location:100 → 773
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:853 → 1930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:35 → 73
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      52384810..52408698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085434.2 → XP_038941362.1  myosin, heavy polypeptide 1, skeletal muscle, adult isoform X1

      UniProtKB/TrEMBL
      F1LRV9
      Conserved Domains (3) summary
      cd14910
      Location:100 → 773
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:853 → 1930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:35 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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