Nexn nexilin (F actin binding protein) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nexnprovided by RGD
Official Full Name: nexilin (F actin binding protein)provided by RGD
Primary source: RGD:708354
See related: EnsemblRapid:ENSRNOG00000012512 AllianceGenome:RGD:708354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables actin filament binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; neuron development; and regulation of cytoskeleton organization. Predicted to act upstream of or within response to bacterium. Located in Z disc and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Orthologous to human NEXN (nexilin F-actin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 446.3), Heart (RPKM 437.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (243846736..243878268, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (241186783..241218315, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (257452937..257484607, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway.
Title: Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway.
Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.
Title: Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	IEA Inferred from Electronic Annotation more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-substrate junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nexilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139230.2 → NP_631976.1 nexilin isoform b

See identical proteins and their annotated locations for NP_631976.1

Status: VALIDATED

Description

Transcript Variant: This variant (b) encodes the longer isoform (b).

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9Z2J3, Q9Z2J4

UniProtKB/TrEMBL

A6HWK8

Related

ENSRNOP00000073825.2, ENSRNOT00000083344.3

Conserved Domains (2) summary

cd00096
Location:579 → 646

Ig; Immunoglobulin domain

pfam07679
Location:562 → 651

I-set; Immunoglobulin I-set domain
NM_139231.2 → NP_631977.1 nexilin isoform s

See identical proteins and their annotated locations for NP_631977.1

Status: VALIDATED

Description

Transcript Variant: This variant (s) has multiple differences in the coding region but maintains the reading frame, compared to variant s. This variant encodes isoform s, which is shorter than isoform b.

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HWK7

Related

ENSRNOP00000058811.4, ENSRNOT00000066780.4

Conserved Domains (2) summary

pfam07679
Location:512 → 601

I-set; Immunoglobulin I-set domain

cd00096
Location:512 → 514

Ig; Ig strand A [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

243846736..243878268 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233479.5 → XP_006233541.1 nexilin isoform X1

See identical proteins and their annotated locations for XP_006233541.1

UniProtKB/TrEMBL

A0A8I5ZUL4, A0A8L2QTU4, A6HWK9

Related

ENSRNOP00000082246.1, ENSRNOT00000111795.2

Conserved Domains (3) summary

PTZ00121
Location:25 → 549

PTZ00121; MAEBL; Provisional

pfam07679
Location:576 → 665

I-set; Immunoglobulin I-set domain

cd00096
Location:576 → 578

Ig; Ig strand A [structural motif]
XM_006233485.4 → XP_006233547.1 nexilin isoform X3

UniProtKB/TrEMBL

A6HWK7

Conserved Domains (2) summary

cd00096
Location:515 → 582

Ig; Immunoglobulin domain

pfam07679
Location:498 → 587

I-set; Immunoglobulin I-set domain
XM_039101727.2 → XP_038957655.1 nexilin isoform X2

UniProtKB/TrEMBL

A6HWK7

Conserved Domains (2) summary

pfam07679
Location:512 → 601

I-set; Immunoglobulin I-set domain

cd00096
Location:512 → 514

Ig; Ig strand A [structural motif]
XM_063281296.1 → XP_063137366.1 nexilin isoform X3
XM_006233480.5 → XP_006233542.1 nexilin isoform X1

See identical proteins and their annotated locations for XP_006233542.1

UniProtKB/TrEMBL

A0A8I5ZUL4, A0A8L2QTU4, A6HWK9

Conserved Domains (3) summary

PTZ00121
Location:25 → 549

PTZ00121; MAEBL; Provisional

pfam07679
Location:576 → 665

I-set; Immunoglobulin I-set domain

cd00096
Location:576 → 578

Ig; Ig strand A [structural motif]
XM_039101726.2 → XP_038957654.1 nexilin isoform X1

UniProtKB/TrEMBL

A0A8I5ZUL4, A0A8L2QTU4, A6HWK9

Conserved Domains (3) summary

PTZ00121
Location:25 → 549

PTZ00121; MAEBL; Provisional

pfam07679
Location:576 → 665

I-set; Immunoglobulin I-set domain

cd00096
Location:576 → 578

Ig; Ig strand A [structural motif]