Asic5 acid sensing ion channel subunit family member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asic5provided by RGD
Official Full Name: acid sensing ion channel subunit family member 5provided by RGD
Primary source: RGD:69295
See related: EnsemblRapid:ENSRNOG00000011842 AllianceGenome:RGD:69295
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Inac; Accn5; Blinac
Summary: Enables ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ASIC5 (acid sensing ion channel subunit family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 2.8), Testes (RPKM 0.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (169606059..169634885)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (167307984..167336812)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (180935392..180964365)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BASIC is strongly activated by ursodeoxycholic acid.
Title: Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid.
rBLINaC is opened by an unknown ligand whereas mBLINaC is a constitutively open epithelial Na(+) channel.
Title: A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC).
regulation by N4WBP5A
Title: Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488718

D2Uia14 (e-PCR)
- UniSTS:240450

NoName (e-PCR)
- UniSTS:493945

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables ligand-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables proton channel activity	ISO Inferred from Sequence Orthology more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acid-sensing ion channel 5

Names: acid-sensing (proton-gated) ion channel family member 5; amiloride-sensitive Na+ channel (BLINaC gene); amiloride-sensitive cation channel 5, intestinal; amiloride-sensitive sodium channel; brain-liver-intestine amiloride-sensitive Na(+) channel; inactivation no afterpotential C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.