Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hnrnph1provided by RGD
Official Full Name: heterogeneous nuclear ribonucleoprotein H1provided by RGD
Primary source: RGD:620840
See related: EnsemblRapid:ENSRNOG00000003399 AllianceGenome:RGD:620840
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hnrph; Hnrph1; hnRNP H
Summary: Enables enzyme binding activity. Involved in cellular response to peptide. Located in nucleoplasm. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in Sjogren's syndrome. Orthologous to human HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 1314.9), Lung (RPKM 954.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (35187412..35203909)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (34692868..34702849)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (35872619..35879911)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HNRNPH is a splicing regulator of Trf2 pre-mRNA that prevents the expression of TRF2-S, a factor implicated in neuronal differentiation.
Title: Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2.
These results establish hnRNP H and hnRNP F as being repressors of exon inclusion and suggest that Fox proteins enhance their ability to antagonize ASF/SF2.
Title: hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G43520 (e-PCR)
- UniSTS:94977

AA900513 (e-PCR)
- UniSTS:248850

Hnrph1 (e-PCR), detects polymorphism
- UniSTS:479124

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA processing	TAS Traceable Author Statement more info	PubMed
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-7	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080896.2 → NP_543172.2 heterogeneous nuclear ribonucleoprotein H

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

A1L1J1, Q8VHV7

UniProtKB/TrEMBL

A6HE17

Related

ENSRNOP00000063584.3, ENSRNOT00000067188.4

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

cd12734
Location:289 → 364

RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

35187412..35203909

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085096.2 → XP_038941024.1 heterogeneous nuclear ribonucleoprotein H isoform X1

UniProtKB/Swiss-Prot

A1L1J1, Q8VHV7

UniProtKB/TrEMBL

A0A8I6G5X8

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

cd12734
Location:289 → 364

RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
XM_063268352.1 → XP_063124422.1 heterogeneous nuclear ribonucleoprotein H isoform X3

UniProtKB/Swiss-Prot

A1L1J1, Q8VHV7

UniProtKB/TrEMBL

A6HE17
XM_039085099.2 → XP_038941027.1 heterogeneous nuclear ribonucleoprotein H isoform X2

UniProtKB/TrEMBL

A0A8I6AGL3, G3V9Q3

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

cd12734
Location:289 → 364

RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
XM_039085094.1 → XP_038941022.1 heterogeneous nuclear ribonucleoprotein H isoform X1

UniProtKB/Swiss-Prot

A1L1J1, Q8VHV7

UniProtKB/TrEMBL

A0A8I6G5X8

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

cd12734
Location:289 → 364

RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
XM_039085101.2 → XP_038941029.1 heterogeneous nuclear ribonucleoprotein H isoform X4

UniProtKB/Swiss-Prot

A1L1J1, Q8VHV7

Related

ENSRNOP00000055962.5, ENSRNOT00000059190.6

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

cd12734
Location:289 → 364

RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
XM_039085095.2 → XP_038941023.1 heterogeneous nuclear ribonucleoprotein H isoform X1

UniProtKB/Swiss-Prot

A1L1J1, Q8VHV7

UniProtKB/TrEMBL

A0A8I6G5X8

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

cd12734
Location:289 → 364

RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
XM_039085097.2 → XP_038941025.1 heterogeneous nuclear ribonucleoprotein H isoform X1

UniProtKB/Swiss-Prot

A1L1J1, Q8VHV7

UniProtKB/TrEMBL

A0A8I6G5X8

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

cd12734
Location:289 → 364

RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
XM_063268353.1 → XP_063124423.1 heterogeneous nuclear ribonucleoprotein H isoform X5