Elob elongin B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Elobprovided by RGD
Official Full Name: elongin Bprovided by RGD
Primary source: RGD:621200
See related: EnsemblRapid:ENSRNOG00000004814 AllianceGenome:RGD:621200
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tceb2
Summary: Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of VCB complex and transcription regulator complex. Orthologous to human ELOB (elongin B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 973.6), Testes (RPKM 948.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (13353413..13358484, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (12848830..12853897, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13163032..13168217, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129535 (e-PCR)
- UniSTS:212837

RH137181 (e-PCR)
- UniSTS:219269

RH44069 (e-PCR)
- UniSTS:50649

TCEB2_3482 (e-PCR)
- UniSTS:462583

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in target-directed miRNA degradation	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul5-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of VCB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of VCB complex	IDA Inferred from Direct Assay more info	PubMed
part_of VCB complex	IEA Inferred from Electronic Annotation more info
part_of elongin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of elongin complex	IEA Inferred from Electronic Annotation more info
part_of elongin complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: elongin-B

Names: RNA polymerase II transcription factor SIII subunit B; SIII p18; elongin 18 kDa subunit; transcription elongation factor B (SIII) polypeptide 2 (18kD, elongin B); transcription elongation factor B (SIII), polypeptide 2; transcription elongation factor B polypeptide 2; transcription elongation factor B subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031129.3 → NP_112391.1 elongin-B

See identical proteins and their annotated locations for NP_112391.1

Status: PROVISIONAL

Source sequence(s)

BC058463

UniProtKB/Swiss-Prot

P62870

UniProtKB/TrEMBL

A0A8L2R5Z8

Conserved Domains (1) summary

cd01788
Location:2 → 102

Ubl_ElonginB; ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar proteins