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    Zfp592 zinc finger protein 592 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp592provided by RGD
    Official Full Name
    zinc finger protein 592provided by RGD
    Primary source
    RGD:1308705
    See related
    EnsemblRapid:ENSRNOG00000060206 AllianceGenome:RGD:1308705
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf592
    Summary
    Predicted to enable PH domain binding activity and insulin receptor substrate binding activity. Predicted to act upstream of or within negative regulation of insulin receptor signaling pathway and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in nucleus. Orthologous to human ZNF592 (zinc finger protein 592). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 65.1), Spleen (RPKM 64.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp592 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144355227..144411686)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134951286..135002443)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142833999..142870997)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26-like 1, pseudogene 1 Neighboring gene neuromedin B Neighboring gene SEC11 homolog A, signal peptidase complex subunit Neighboring gene alpha-kinase 3 Neighboring gene solute carrier family 28 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PH domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin receptor substrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 592

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106272.1 → NP_001099742.1  zinc finger protein 592

      See identical proteins and their annotated locations for NP_001099742.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473980
      UniProtKB/TrEMBL
      A6JCE7, D3ZJG8
      Conserved Domains (3) summary
      PTZ00449
      Location:252 → 439
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      sd00017
      Location:983 → 1003
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:1147 → 1175
      zf-C2H2_11; zinc-finger C2H2-type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144355227..144411686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105592.2 → XP_038961520.1  zinc finger protein 592 isoform X1

      UniProtKB/TrEMBL
      A6JCE7, D3ZJG8
      Related
      ENSRNOP00000070618.1, ENSRNOT00000091569.3
      Conserved Domains (3) summary
      PTZ00449
      Location:252 → 439
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      sd00017
      Location:983 → 1003
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:1147 → 1175
      zf-C2H2_11; zinc-finger C2H2-type

    2. XM_039105598.2 → XP_038961526.1  zinc finger protein 592 isoform X1

      UniProtKB/TrEMBL
      A6JCE7, D3ZJG8
      Conserved Domains (3) summary
      PTZ00449
      Location:252 → 439
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      sd00017
      Location:983 → 1003
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:1147 → 1175
      zf-C2H2_11; zinc-finger C2H2-type

    RNA

    1. XR_005501949.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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