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    Zfp444 zinc finger protein 444 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292569, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp444provided by RGD
    Official Full Name
    zinc finger protein 444provided by RGD
    Primary source
    RGD:1304847
    See related
    EnsemblRapid:ENSRNOG00000015517 AllianceGenome:RGD:1304847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf444
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF444 (zinc finger protein 444). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 118.3), Kidney (RPKM 97.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp444 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (76741399..76762388, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (67709052..67729283, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (71380856..71400781, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 5B Neighboring gene galanin-like peptide Neighboring gene zinc finger protein 787 Neighboring gene NLR family, pyrin domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 444

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169143.1 → NP_001162614.1  zinc finger protein 444

      See identical proteins and their annotated locations for NP_001162614.1

      Status: VALIDATED

      Source sequence(s)
      FM030255, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KS79, D3ZV88
      Related
      ENSRNOP00000020787.4, ENSRNOT00000020787.8
      Conserved Domains (4) summary
      COG5048
      Location:188 → 286
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain
      pfam13465
      Location:202 → 227
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      76741399..76762388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228186.5 → XP_006228248.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006228248.1

      UniProtKB/TrEMBL
      A6KS79, D3ZV88
      Conserved Domains (4) summary
      COG5048
      Location:188 → 286
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain
      pfam13465
      Location:202 → 227
      zf-H2C2_2; Zinc-finger double domain

    2. XM_008758902.4 → XP_008757124.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_008757124.1

      UniProtKB/TrEMBL
      A6KS79, D3ZV88
      Conserved Domains (4) summary
      COG5048
      Location:188 → 286
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:26 → 103
      SCAN; SCAN domain
      pfam13465
      Location:202 → 227
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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