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    Mrrf mitochondrial ribosome recycling factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrrfprovided by RGD
    Official Full Name
    mitochondrial ribosome recycling factorprovided by RGD
    Primary source
    RGD:1305897
    See related
    EnsemblRapid:ENSRNOG00000025997 AllianceGenome:RGD:1305897
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosome disassembly and translation. Predicted to be active in mitochondrion. Orthologous to human MRRF (mitochondrial ribosome recycling factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 93.7), Adrenal (RPKM 68.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrrf in Genome Data Viewer
    Location:
    3p11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (39884530..39941317)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (19487124..19543911)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (15463884..15520621)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene MORN repeat containing 5 Neighboring gene uncharacterized LOC134486080 Neighboring gene LIM homeobox 6 Neighboring gene RNA binding motif protein 18 Neighboring gene uncharacterized LOC120101536 Neighboring gene prostaglandin-endoperoxide synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. Tsuboi M, et al. Mol Cell, 2009 Aug 28. PMID 19716793
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93722

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ribosome-recycling factor, mitochondrial
    Names
    RRF
    ribosome-releasing factor, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008354.1 → NP_001008355.1  ribosome-recycling factor, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001008355.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085779
      UniProtKB/Swiss-Prot
      Q5RKI9
      Related
      ENSRNOP00000038041.3, ENSRNOT00000033047.5
      Conserved Domains (1) summary
      pfam01765
      Location:99 → 260
      RRF; Ribosome recycling factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      39884530..39941317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105267.1 → XP_038961195.1  ribosome-recycling factor, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I6G9D1
      Related
      ENSRNOP00000083698.1, ENSRNOT00000113456.2
      Conserved Domains (1) summary
      pfam01765
      Location:99 → 184
      RRF; Ribosome recycling factor

    2. XM_006234069.3 → XP_006234131.1  ribosome-recycling factor, mitochondrial isoform X3

      Conserved Domains (1) summary
      pfam01765
      Location:64 → 208
      RRF; Ribosome recycling factor

    3. XM_063283974.1 → XP_063140044.1  ribosome-recycling factor, mitochondrial isoform X4

    4. XM_063283975.1 → XP_063140045.1  ribosome-recycling factor, mitochondrial isoform X6

    5. XM_039105266.2 → XP_038961194.1  ribosome-recycling factor, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q5RKI9
      Conserved Domains (1) summary
      pfam01765
      Location:99 → 260
      RRF; Ribosome recycling factor

    6. XM_063283973.1 → XP_063140043.1  ribosome-recycling factor, mitochondrial isoform X3

    7. XM_039105268.1 → XP_038961196.1  ribosome-recycling factor, mitochondrial isoform X5

      Conserved Domains (1) summary
      pfam01765
      Location:8 → 169
      RRF; Ribosome recycling factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RKI9.1 GenPept UniProtKB/Swiss-Prot:Q5RKI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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