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    Aar2 AAR2 splicing factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296312, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Aar2provided by RGD
    Official Full Name
    AAR2 splicing factorprovided by RGD
    Primary source
    RGD:1311066
    See related
    EnsemblRapid:ENSRNOG00000020086 AllianceGenome:RGD:1311066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311066
    Summary
    Predicted to be involved in spliceosomal tri-snRNP complex assembly. Orthologous to human AAR2 (AAR2 splicing factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 58.5), Adrenal (RPKM 49.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aar2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165517467..165540260)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145057368..145079838)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152626738..152648365)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide binding domain containing 2 Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene ferritin light chain 1 pseudogene Neighboring gene erythrocyte membrane protein band 4.1-like 1 Neighboring gene uncharacterized LOC120101765 Neighboring gene uncharacterized LOC120101766

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural analyses of the pre-mRNA splicing machinery. Zhang L, et al. Protein Sci, 2013 Jun. PMID 23592432, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein AAR2 homolog
    Names
    AAR2 splicing factor homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106535.2 → NP_001100005.1  protein AAR2 homolog

      See identical proteins and their annotated locations for NP_001100005.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KIB2, B1WC03, F7F4I3
      Conserved Domains (3) summary
      cd13777
      Location:19 → 148
      Aar2_N; N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      cd13778
      Location:205 → 359
      Aar2_C; C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      pfam05282
      Location:17 → 363
      AAR2; AAR2 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      165517467..165540260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235399.5 → XP_006235461.1  protein AAR2 homolog isoform X2

      See identical proteins and their annotated locations for XP_006235461.1

      UniProtKB/TrEMBL
      A6KIB2, B1WC03, F7F4I3
      Conserved Domains (3) summary
      cd13777
      Location:19 → 148
      Aar2_N; N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      cd13778
      Location:205 → 359
      Aar2_C; C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      pfam05282
      Location:17 → 363
      AAR2; AAR2 protein

    2. XM_039104615.2 → XP_038960543.1  protein AAR2 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0P7
      Related
      ENSRNOP00000071534.2, ENSRNOT00000086425.3
      Conserved Domains (1) summary
      pfam05282
      Location:53 → 399
      AAR2; AAR2 protein

    3. XM_063283376.1 → XP_063139446.1  protein AAR2 homolog isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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