Foxp1 forkhead box P1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxp1provided by RGD
Official Full Name: forkhead box P1provided by RGD
Primary source: RGD:1308669
See related: EnsemblRapid:ENSRNOG00000009184 AllianceGenome:RGD:1308669
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; nuclear androgen receptor binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to tumor necrosis factor; negative regulation of cell growth involved in cardiac muscle cell development; and positive regulation of hydrogen peroxide-mediated programmed cell death. Predicted to be active in nucleus. Biomarker of hepatocellular carcinoma; lung adenocarcinoma; and trichostrongyloidiasis. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; congenital heart disease; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 155.1), Spleen (RPKM 137.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (133117346..133808647, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (131559599..132155092, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (131362178..131963466, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to Suppress Angiogenesis.
Title: MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to Suppress Angiogenesis.
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Title: Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells.
Title: miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells.
Both Pnoc and FoxP1 were expressed at high levels in the rostromedial tegmental nucleus and colocalized strongly with previously established RMTg markers. FoxP1 was particularly selective for RMTg neurons, as it was absent in most adjacent brain regions.
Title: Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice.
The results indicate that FOXP1 plays a crucial role in tendon-derived stem/progenitor cell aging.
Title: Downregulation of FOXP1 correlates with tendon stem/progenitor cells aging.
Study shows that FOXP1 is SUMOylated at K670 in rat neurons and this is required for efficient transcriptional repression, likely by promoting binding to the transcriptional co-repressor CtBP1. FOXP1 SUMOylation is regulated via calcium entry through both NMDA receptors and L-type calcium channels. Thus, FOXP1 SUMOylation is essential for neuronal morphogenesis.
Title: SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis.
Androgen effects on both Foxp2 and Foxp1 were found to occur in the striatum, cerebellar vermis, and cortex.
Title: Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140136 (e-PCR)
- UniSTS:222215

d4arb16 (e-PCR)
- UniSTS:121907

d4mit18 (e-PCR)
- UniSTS:121928

RH142550 (e-PCR)
- UniSTS:231797

D4Wox17 (e-PCR)
- UniSTS:239479

RH138314 (e-PCR)
- UniSTS:220401

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in T follicular helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial cell activation	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin V(D)J recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of innate vocalization behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung secretory cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in motor neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lung goblet cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-21 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pre-B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lung goblet cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in striatum development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in ventral spinal cord development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: forkhead box protein P1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034131.2 → NP_001029303.1 forkhead box protein P1

See identical proteins and their annotated locations for NP_001029303.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q498D1

UniProtKB/TrEMBL

A0A8I6A8D7, A0A8I6AJR4

Related

ENSRNOP00000095477.1, ENSRNOT00000100443.2

Conserved Domains (2) summary

cd00059
Location:499 → 571

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:336 → 403

FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

133117346..133808647 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285823.1 → XP_063141893.1 forkhead box protein P1 isoform X1
XM_063285827.1 → XP_063141897.1 forkhead box protein P1 isoform X5
XM_063285826.1 → XP_063141896.1 forkhead box protein P1 isoform X4
XM_063285824.1 → XP_063141894.1 forkhead box protein P1 isoform X2
XM_063285825.1 → XP_063141895.1 forkhead box protein P1 isoform X3
XM_063285822.1 → XP_063141892.1 forkhead box protein P1 isoform X1
XM_063285835.1 → XP_063141905.1 forkhead box protein P1 isoform X9

Related

ENSRNOP00000013271.6, ENSRNOT00000013271.8
XM_063285832.1 → XP_063141902.1 forkhead box protein P1 isoform X8
XM_063285831.1 → XP_063141901.1 forkhead box protein P1 isoform X7
XM_063285828.1 → XP_063141898.1 forkhead box protein P1 isoform X6

UniProtKB/Swiss-Prot

Q498D1
XM_039107379.2 → XP_038963307.1 forkhead box protein P1 isoform X1

UniProtKB/TrEMBL

A0A8I6A8D7, A0A8I6AJR4

Conserved Domains (3) summary

COG5025
Location:493 → 707

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:358 → 425

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:520 → 601

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_039107389.2 → XP_038963317.1 forkhead box protein P1 isoform X22

UniProtKB/TrEMBL

A6IBG6

Conserved Domains (3) summary

COG5025
Location:470 → 683

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:335 → 402

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:496 → 577

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_039107378.2 → XP_038963306.1 forkhead box protein P1 isoform X1

UniProtKB/TrEMBL

A0A8I6A8D7, A0A8I6AJR4

Conserved Domains (3) summary

COG5025
Location:493 → 707

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:358 → 425

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:520 → 601

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_063285829.1 → XP_063141899.1 forkhead box protein P1 isoform X6

UniProtKB/Swiss-Prot

Q498D1
XM_063285833.1 → XP_063141903.1 forkhead box protein P1 isoform X8
XM_039107381.2 → XP_038963309.1 forkhead box protein P1 isoform X1

UniProtKB/TrEMBL

A0A8I6A8D7, A0A8I6AJR4

Conserved Domains (3) summary

COG5025
Location:493 → 707

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:358 → 425

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:520 → 601

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_063285834.1 → XP_063141904.1 forkhead box protein P1 isoform X8
XM_063285830.1 → XP_063141900.1 forkhead box protein P1 isoform X6

UniProtKB/Swiss-Prot

Q498D1
XM_039107382.2 → XP_038963310.1 forkhead box protein P1 isoform X1

UniProtKB/TrEMBL

A0A8I6A8D7, A0A8I6AJR4

Conserved Domains (3) summary

COG5025
Location:493 → 707

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:358 → 425

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:520 → 601

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_039107388.2 → XP_038963316.1 forkhead box protein P1 isoform X12

UniProtKB/TrEMBL

A0A8I6A8D7

Conserved Domains (3) summary

COG5025
Location:432 → 646

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:297 → 364

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:459 → 540

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_063285836.1 → XP_063141906.1 forkhead box protein P1 isoform X11
XM_039107387.2 → XP_038963315.1 forkhead box protein P1 isoform X10

UniProtKB/TrEMBL

A0A8I6A8D7

Conserved Domains (3) summary

COG5025
Location:454 → 668

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:319 → 386

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:481 → 562

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_017592562.3 → XP_017448051.1 forkhead box protein P1 isoform X16

UniProtKB/TrEMBL

A0A8I6A8D7

Conserved Domains (3) summary

COG5025
Location:339 → 553

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:204 → 271

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:366 → 447

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_063285841.1 → XP_063141911.1 forkhead box protein P1 isoform X18

UniProtKB/TrEMBL

A0A8I5ZVX5
XM_063285844.1 → XP_063141914.1 forkhead box protein P1 isoform X20
XM_063285840.1 → XP_063141910.1 forkhead box protein P1 isoform X17
XM_063285842.1 → XP_063141912.1 forkhead box protein P1 isoform X19
XM_063285838.1 → XP_063141908.1 forkhead box protein P1 isoform X14
XM_063285839.1 → XP_063141909.1 forkhead box protein P1 isoform X15
XM_063285837.1 → XP_063141907.1 forkhead box protein P1 isoform X13
XM_063285845.1 → XP_063141915.1 forkhead box protein P1 isoform X21
XM_006236955.5 → XP_006237017.1 forkhead box protein P1 isoform X16

See identical proteins and their annotated locations for XP_006237017.1

UniProtKB/TrEMBL

A0A8I6A8D7

Conserved Domains (3) summary

COG5025
Location:339 → 553

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:204 → 271

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:366 → 447

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006236954.5 → XP_006237016.1 forkhead box protein P1 isoform X16

See identical proteins and their annotated locations for XP_006237016.1

UniProtKB/TrEMBL

A0A8I6A8D7

Conserved Domains (3) summary

COG5025
Location:339 → 553

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:204 → 271

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:366 → 447

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_006236956.4 → XP_006237018.1 forkhead box protein P1 isoform X17

UniProtKB/TrEMBL

A0A8I6A8D7

Conserved Domains (2) summary

cd00059
Location:366 → 438

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:203 → 270

FOXP-CC; FOXP coiled-coil domain
XM_063285843.1 → XP_063141913.1 forkhead box protein P1 isoform X19