Rtn4rl1 reticulon 4 receptor-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rtn4rl1provided by RGD
Official Full Name: reticulon 4 receptor-like 1provided by RGD
Primary source: RGD:727812
See related: EnsemblRapid:ENSRNOG00000003121 AllianceGenome:RGD:727812
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ngrh2
Summary: Predicted to enable Roundabout binding activity; glycosaminoglycan binding activity; and signaling receptor activity. Predicted to be involved in negative chemotaxis; negative regulation of axon regeneration; and nervous system development. Located in cell surface. Orthologous to human RTN4RL1 (reticulon 4 receptor like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 109.9), Thymus (RPKM 84.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (60541584..60615302)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (60043246..60116977)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (62035866..62109075)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

spatio-temporal expression pattern of NgR1, NgR2 & NgR3 mRNAs & corresponding proteins in developing olfactory system; data suggest, in non-pathological conditions, NgR1 & homologs may play a role in axon outgrowth in the olfactory system.
Title: Spatio-temporal expression pattern of receptors for myelin-associated inhibitors in the developing rat olfactory system.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132145 (e-PCR)
- UniSTS:215428

Rtn4rl1 (e-PCR), detects polymorphism
- UniSTS:547535

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Roundabout binding	IBA Inferred from Biological aspect of Ancestor more info
enables chondroitin sulfate binding	IEA Inferred from Electronic Annotation more info
enables chondroitin sulfate binding	ISO Inferred from Sequence Orthology more info
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
involved_in corpus callosum development	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: reticulon-4 receptor-like 1

Names: Nogo-66 receptor homolog 2; ngR3; nogo receptor-like 2; nogo-66 receptor-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181377.3 → NP_852042.1 reticulon-4 receptor-like 1 precursor

See identical proteins and their annotated locations for NP_852042.1

Status: PROVISIONAL

Source sequence(s)

BC129084

UniProtKB/Swiss-Prot

A1L1I9, Q7TQ96, Q80WD0

UniProtKB/TrEMBL

A0A8I6A6E3, A6HGP8

Related

ENSRNOP00000058866.1, ENSRNOT00000067414.5

Conserved Domains (3) summary

sd00033
Location:78 → 101

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:174 → 233

LRR_8; Leucine rich repeat

cd21340
Location:126 → 255

PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

60541584..60615302

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086015.2 → XP_038941943.1 reticulon-4 receptor-like 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A6E3, A0A8I6B1X8

Related

ENSRNOP00000099059.1, ENSRNOT00000149380.1

Conserved Domains (3) summary

sd00033
Location:43 → 66

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:139 → 198

LRR_8; Leucine rich repeat

cd21340
Location:91 → 220

PPP1R42; protein phosphatase 1 regulatory subunit 42