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    Ecscr endothelial cell surface expressed chemotaxis and apoptosis regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ecscrprovided by RGD
    Official Full Name
    endothelial cell surface expressed chemotaxis and apoptosis regulatorprovided by RGD
    Primary source
    RGD:1594804
    See related
    EnsemblRapid:ENSRNOG00000039593 AllianceGenome:RGD:1594804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aria; Ecscr-ps1
    Summary
    Predicted to be involved in negative regulation of angiogenesis; positive regulation of endothelial cell apoptotic process; and positive regulation of proteasomal protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and plasma membrane. Orthologous to human ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 44.3), Heart (RPKM 18.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ecscr in Genome Data Viewer
    Location:
    18p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27583791..27593184, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27309711..27319106, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28507167..28516567, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 24 Neighboring gene DnaJ heat shock protein family (Hsp40) member C18 Neighboring gene small integral membrane protein 33 Neighboring gene stimulator of interferon response cGAMP interactor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy. Kitamura Y, et al. J Biol Chem, 2014 Jan 31. PMID 24338479, Free PMC Article
    2. Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. Ikeda K, et al. Proc Natl Acad Sci U S A, 2009 May 19. PMID 19416853, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These studies, reveal a previously undescribed mode of manipulating cardiac PI3K/Akt signaling by ARIA, thus identifying it as an attractive new target for the prevention of stress-induced myocardial dysfunction.
      Title: Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endothelial cell surface expressed chemotaxis and apoptosis regulator; endothelial cell-specific chemotaxis regulator
    Names
    apoptosis regulator through modulating IAP expression
    endothelial cell-specific chemotaxis regulator, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432559.1 → NP_001419488.1  endothelial cell surface expressed chemotaxis and apoptosis regulator isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6A8X7, A0A8I6G5C4

    2. NM_001432560.1 → NP_001419489.1  endothelial cell surface expressed chemotaxis and apoptosis regulator isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6A6Y3, A6J2Z3, M0RCJ4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      27583791..27593184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601093.3 → XP_017456582.1  endothelial cell-specific chemotaxis regulator isoform X5

      UniProtKB/TrEMBL
      A0A8I6A8X7

    2. XM_063277650.1 → XP_063133720.1  endothelial cell-specific chemotaxis regulator isoform X7

      UniProtKB/TrEMBL
      A0A8I6A8X7

    3. XM_017601091.3 → XP_017456580.1  endothelial cell-specific chemotaxis regulator isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8X7
      Related
      ENSRNOP00000079454.2, ENSRNOT00000120258.2

    4. XM_017601092.3 → XP_017456581.1  endothelial cell-specific chemotaxis regulator isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8X7

    5. XM_008772057.4 → XP_008770279.1  endothelial cell-specific chemotaxis regulator isoform X4

      Related
      ENSRNOP00000067313.2, ENSRNOT00000072580.5
      Conserved Domains (1) summary
      pfam15820
      Location:125 → 222
      ECSCR; Endothelial cell-specific chemotaxis regulator

    6. XM_063277649.1 → XP_063133719.1  endothelial cell-specific chemotaxis regulator isoform X6

    7. XM_039097302.2 → XP_038953230.1  endothelial cell-specific chemotaxis regulator isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8X7
      Related
      ENSRNOP00000087965.2, ENSRNOT00000097911.2
      Conserved Domains (1) summary
      pfam15820
      Location:145 → 242
      ECSCR; Endothelial cell-specific chemotaxis regulator
    Nucleotide Protein Strain
    Heading Accession and Version

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