Nabp1 nucleic acid binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nabp1provided by RGD
Official Full Name: nucleic acid binding protein 1provided by RGD
Primary source: RGD:1306658
See related: EnsemblRapid:ENSRNOG00000015416 AllianceGenome:RGD:1306658
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Obfc2a; RGD1306658
Summary: Predicted to enable RNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Predicted to be located in chromosome; cytosol; and nucleoplasm. Predicted to be part of SOSS complex. Orthologous to human NABP1 (nucleic acid binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 225.6), Thymus (RPKM 225.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (57570326..57625926)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (50098552..50133982)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (55049893..55057784)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G2/M transition checkpoint	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2/M transition checkpoint	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ionizing radiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SOSS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SOSS complex	ISO Inferred from Sequence Orthology more info
part_of SOSS complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SOSS complex subunit B2

Names: SOSS-B2; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; sensor of single-strand DNA complex subunit B2; sensor of ssDNA subunit B2; single-stranded DNA-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014216.2 → NP_001014238.1 SOSS complex subunit B2

See identical proteins and their annotated locations for NP_001014238.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q5FVP2

UniProtKB/TrEMBL

A6INX2

Related

ENSRNOP00000021403.3, ENSRNOT00000021403.7

Conserved Domains (1) summary

cd04491
Location:22 → 99

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

57570326..57625926

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267373.1 → XP_063123443.1 SOSS complex subunit B2 isoform X1

UniProtKB/TrEMBL

A6INX4
XM_039083850.2 → XP_038939778.1 SOSS complex subunit B2 isoform X3

Conserved Domains (1) summary

cd04491
Location:4 → 73

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_017596514.3 → XP_017452003.1 SOSS complex subunit B2 isoform X1

UniProtKB/TrEMBL

A6INX4
XM_039083849.2 → XP_038939777.1 SOSS complex subunit B2 isoform X2

Conserved Domains (1) summary

cd04491
Location:22 → 99

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_039083851.2 → XP_038939779.1 SOSS complex subunit B2 isoform X1

UniProtKB/TrEMBL

A6INX4