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    Lrrc56 leucine rich repeat containing 56 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365389, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc56provided by RGD
    Official Full Name
    leucine rich repeat containing 56provided by RGD
    Primary source
    RGD:1311654
    See related
    EnsemblRapid:ENSRNOG00000016697 AllianceGenome:RGD:1311654
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311654
    Summary
    Predicted to be involved in cell projection organization. Predicted to be located in cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 39. Orthologous to human LRRC56 (leucine rich repeat containing 56). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 125.3), Lung (RPKM 26.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc56 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205729402..205744754)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196299843..196315170)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214182232..214197184)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene HRas proto-oncogene, GTPase Neighboring gene lamin tail domain containing 2 Neighboring gene Ras association domain family member 7 Neighboring gene uncharacterized LOC102553043 Neighboring gene microRNA 3574 Neighboring gene microRNA 210

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114503

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 56

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024902.1 → NP_001020073.1  leucine-rich repeat-containing protein 56

      See identical proteins and their annotated locations for NP_001020073.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097444
      UniProtKB/Swiss-Prot
      Q4V8C9
      UniProtKB/TrEMBL
      A6HXQ9, A6HXR2
      Conserved Domains (2) summary
      sd00033
      Location:95 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:91 → 233
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205729402..205744754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230565.5 → XP_006230627.1  leucine-rich repeat-containing protein 56 isoform X1

      See identical proteins and their annotated locations for XP_006230627.1

      UniProtKB/Swiss-Prot
      Q4V8C9
      UniProtKB/TrEMBL
      A6HXQ9, A6HXR2
      Related
      ENSRNOP00000107955.1, ENSRNOT00000163683.1
      Conserved Domains (2) summary
      sd00033
      Location:95 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:91 → 233
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_063269752.1 → XP_063125822.1  leucine-rich repeat-containing protein 56 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K846
      Related
      ENSRNOP00000074468.2, ENSRNOT00000091150.3

    3. XM_063269733.1 → XP_063125803.1  leucine-rich repeat-containing protein 56 isoform X1

      UniProtKB/Swiss-Prot
      Q4V8C9
      UniProtKB/TrEMBL
      A6HXQ9

    4. XM_063269742.1 → XP_063125812.1  leucine-rich repeat-containing protein 56 isoform X2

    5. XM_017589500.3 → XP_017444989.1  leucine-rich repeat-containing protein 56 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K846
      Conserved Domains (4) summary
      cd00116
      Location:54 → 192
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:95 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:140 → 175
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:117 → 172
      LRR_8; Leucine rich repeat

    6. XM_063269755.1 → XP_063125825.1  leucine-rich repeat-containing protein 56 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K846

    7. XM_006230564.5 → XP_006230626.1  leucine-rich repeat-containing protein 56 isoform X1

      See identical proteins and their annotated locations for XP_006230626.1

      UniProtKB/Swiss-Prot
      Q4V8C9
      UniProtKB/TrEMBL
      A6HXQ9, A6HXR2
      Conserved Domains (2) summary
      sd00033
      Location:95 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:91 → 233
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    8. XM_063269751.1 → XP_063125821.1  leucine-rich repeat-containing protein 56 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K846

    9. XM_063269761.1 → XP_063125831.1  leucine-rich repeat-containing protein 56 isoform X5

    10. XM_017589499.3 → XP_017444988.1  leucine-rich repeat-containing protein 56 isoform X2

      UniProtKB/TrEMBL
      A6HXR2
      Related
      ENSRNOP00000022867.5, ENSRNOT00000022867.8

    11. XM_039085390.2 → XP_038941318.1  leucine-rich repeat-containing protein 56 isoform X1

      UniProtKB/Swiss-Prot
      Q4V8C9
      UniProtKB/TrEMBL
      A6HXQ9, A6HXR2
      Conserved Domains (2) summary
      sd00033
      Location:95 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:91 → 233
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    12. XM_063269753.1 → XP_063125823.1  leucine-rich repeat-containing protein 56 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K846

    13. XM_006230570.5 → XP_006230632.1  leucine-rich repeat-containing protein 56 isoform X3

      See identical proteins and their annotated locations for XP_006230632.1

      UniProtKB/TrEMBL
      A6HXR1, A6HXR2
      Conserved Domains (3) summary
      sd00033
      Location:20 → 42
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:65 → 100
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:42 → 97
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8C9.1 GenPept UniProtKB/Swiss-Prot:Q4V8C9

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