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    Pcgf6 polycomb group ring finger 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309457, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pcgf6provided by RGD
    Official Full Name
    polycomb group ring finger 6provided by RGD
    Primary source
    RGD:1306904
    See related
    EnsemblRapid:ENSRNOG00000020250 AllianceGenome:RGD:1306904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf134
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in chromatin remodeling and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Orthologous to human PCGF6 (polycomb group ring finger 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 86.8), Thymus (RPKM 47.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcgf6 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255866709..255886306, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245925354..245944964, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266811418..266831022, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene transfer RNA arginine (anticodon UCU) 2 Neighboring gene internexin neuronal intermediate filament protein, alpha Neighboring gene TATA-box binding protein associated factor 5 Neighboring gene ATP synthase membrane subunit K Neighboring gene programmed cell death 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. Kanno M, et al. EMBO J, 1995 Nov 15. PMID 8521824, Free PMC Article
    2. MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation. Akasaka T, et al. Genes Cells, 2002 Aug. PMID 12167161
    3. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Taherbhoy AM, et al. Nat Commun, 2015 Jul 7. PMID 26151332
    4. PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Almeida M, et al. Science, 2017 Jun 9. PMID 28596365, Free PMC Article
    5. PRC1 complex diversity: where is it taking us? Gil J, et al. Trends Cell Biol, 2014 Nov. PMID 25065329

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PRC1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of PcG protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polycomb group RING finger protein 6
    Names
    ring finger protein 134

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013154.1 → NP_001013172.1  polycomb group RING finger protein 6

      See identical proteins and their annotated locations for NP_001013172.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083820
      UniProtKB/Swiss-Prot
      Q5XI70
      Related
      ENSRNOP00000112266.1, ENSRNOT00000131590.1
      Conserved Domains (2) summary
      cd16738
      Location:131 → 175
      RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
      cd17085
      Location:253 → 342
      RAWUL_PCGF6; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      255866709..255886306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760438.4 → XP_008758660.1  polycomb group RING finger protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5XW83
      Related
      ENSRNOP00000077535.1, ENSRNOT00000094399.2
      Conserved Domains (3) summary
      COG5222
      Location:135 → 258
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16738
      Location:131 → 175
      RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
      cd17085
      Location:261 → 356
      RAWUL_PCGF6; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

    2. XM_006231509.5 → XP_006231571.1  polycomb group RING finger protein 6 isoform X3

      Conserved Domains (2) summary
      cd16738
      Location:131 → 175
      RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
      cd17085
      Location:253 → 348
      RAWUL_PCGF6; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

    3. XM_008760437.4 → XP_008758659.1  polycomb group RING finger protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QF06
      Related
      ENSRNOP00000027450.4, ENSRNOT00000027450.6
      Conserved Domains (3) summary
      COG5222
      Location:135 → 258
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16738
      Location:131 → 175
      RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
      cd17085
      Location:261 → 350
      RAWUL_PCGF6; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

    RNA

    1. XR_005487580.2 RNA Sequence

    2. XR_005487581.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI70.1 GenPept UniProtKB/Swiss-Prot:Q5XI70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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