Adnp activity-dependent neuroprotector homeobox [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adnpprovided by RGD
Official Full Name: activity-dependent neuroprotector homeoboxprovided by RGD
Primary source: RGD:71030
See related: EnsemblRapid:ENSRNOG00000010975 AllianceGenome:RGD:71030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. [provided by RefSeq, Nov 2016]
Expression: Biased expression in Thymus (RPKM 258.5), Adrenal (RPKM 256.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (177310258..177340379, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (156886921..156921500, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (164937188..164964819, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Moderate Physical Activity Increases the Expression of ADNP in Rat Brain.
Title: Moderate Physical Activity Increases the Expression of ADNP in Rat Brain.
These findings demonstrate that the down-regulation of protein ADNP is an early pathological alteration and may contribute to dopaminergic neurodegeneration in Parkinson's disease
Title: Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.
the newly identified shared microtubule target of NAP/ADNP is directly implicated in synaptic plasticity, explaining the breadth and efficiency of neuroprotective/neurotrophic capacities
Title: The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins.
NAP is an ADNP derived peptide that modulates the tubulin pool in mice and rats
Title: The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities.
An endogenous PACAP-mediated ADNP signaling system increases malignant peripheral nerve sheath tumor cell resistance to hydrogen-peroxide-induced death upon serum starvation.
Title: Involvement of PACAP/ADNP signaling in the resistance to cell death in malignant peripheral nerve sheath tumor (MPNST) cells.
Results suggest that nitric oxide regulates activity-dependent neuroprotective protein in the dentate gyrus under both basal and pathophysiological conditions.
Title: Nitric oxide regulates activity-dependent neuroprotective protein (ADNP) in the dentate gyrus of the rodent model of kainic acid-induced seizure.
These findings identify a mechanism for ADNP regulation of glial-neuronal interactions in developing cerebellum and a pathogenesis of ethanol neurotoxicity.
Title: Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.
These observations suggest a complex interaction of NO-NGF with PPTA/SP and ADNP-VIP in neuron-glial communication when neurons are stressed.
Title: Nitric oxide-NGF mediated PPTA/SP, ADNP, and VIP expression in the peripheral nervous system.
Widespread expression of ADNP may correlate with wide-ranging protective effects, and the cytoplasmic and axonal localisation of ADNP-like immunoreactivity suggests additional, non-transcriptional functions of ADNP.
Title: Expression of activity-dependent neuroprotective protein in the brain of adult rats.
NAPVSIPQ peptide component was shown to inhibit Abeta aggregation; part of the neuroprotective mechanism is through modulation of toxic protein folding in the extracellular milieu
Title: The neuroprotective peptide NAP inhibits the aggregation of the beta-amyloid peptide.

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General gene information

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Markers

RH134339 (e-PCR)
- UniSTS:217621

Adnp (e-PCR), detects polymorphism
- UniSTS:502693

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular nitric oxide homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in short-term memory	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: activity-dependent neuroprotector homeobox protein

Names: NAP peptide; activity-dependent neuroprotective protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429485.1 → NP_001416414.1 activity-dependent neuroprotector homeobox protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

G3V7G3, Q9JKL8
NM_001429486.1 → NP_001416415.1 activity-dependent neuroprotector homeobox protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

G3V7G3, Q9JKL8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

177310258..177340379 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105809.2 → XP_038961737.1 activity-dependent neuroprotector homeobox protein isoform X1

UniProtKB/Swiss-Prot

G3V7G3, Q9JKL8

Conserved Domains (3) summary

smart00389
Location:768 → 811

HOX; Homeodomain

sd00020
Location:491 → 510

ZF_C2H2; C2H2 Zn finger [structural motif]

NF033845
Location:890 → 1087

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039105806.2 → XP_038961734.1 activity-dependent neuroprotector homeobox protein isoform X1

Conserved Domains (3) summary

smart00389
Location:768 → 811

HOX; Homeodomain

sd00020
Location:491 → 510

ZF_C2H2; C2H2 Zn finger [structural motif]

NF033845
Location:890 → 1087

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039105808.2 → XP_038961736.1 activity-dependent neuroprotector homeobox protein isoform X1

Conserved Domains (3) summary

smart00389
Location:768 → 811

HOX; Homeodomain

sd00020
Location:491 → 510

ZF_C2H2; C2H2 Zn finger [structural motif]

NF033845
Location:890 → 1087

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001347532.3: Suppressed sequence

Description

NM_001347532.3: This RefSeq was removed because currently there is insufficient support for the transcript.
NM_022681.2: Suppressed sequence

Description

NM_022681.2: This RefSeq was removed because currently there is insufficient support for the transcript.