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    Ppa1 inorganic pyrophosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppa1provided by RGD
    Official Full Name
    inorganic pyrophosphatase 1provided by RGD
    Primary source
    RGD:1589773
    See related
    EnsemblRapid:ENSRNOG00000063854 AllianceGenome:RGD:1589773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pp; Pyp
    Summary
    Predicted to enable pyrophosphatase activity. Predicted to be involved in intracellular protein transport and phosphate-containing compound metabolic process. Predicted to be located in Golgi cisterna membrane; cytosol; and endoplasmic reticulum membrane. Orthologous to human PPA1 (inorganic pyrophosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 487.9), Heart (RPKM 307.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppa1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (30132088..30160492)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (29590733..29617711)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (31265519..31292451)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 20 Neighboring gene ribosomal protein L27, pseudogene 8 Neighboring gene uncharacterized LOC134483917 Neighboring gene neuropeptide FF receptor 1 Neighboring gene secretion associated, Ras related GTPase 1A Neighboring gene trypsin like peroxisomal matrix peptidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and functional analysis of rat liver cytosolic inorganic pyrophosphatase gene and characterization of its functional promoter. Panda H, et al. Gene Expr, 2007. PMID 17933215, Free PMC Article
    2. Age-dependent differential expression and activity of rat liver cytosolic inorganic pyrophosphatase gene. Panda H, et al. Biogerontology, 2007 Oct. PMID 17415680
    3. Studies on human erythrocyte inorganic pyrophosphatase. Fisher RA, et al. Ann Hum Genet, 1974 Jan. PMID 4130389
    4. Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase. Thuillier L. Biochim Biophys Acta, 1978 May 11. PMID 656444
    5. Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Yasue M, et al. Cytogenet Cell Genet, 1991. PMID 1914521

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There is an age-associated increase (approximately 2-fold) in the expression of rat liver cytosolic iPPase gene by differential display PCR and northern blot analysis.
      Title: Age-dependent differential expression and activity of rat liver cytosolic inorganic pyrophosphatase gene.
    2. Cloning, expression, and functional analysis of rat liver cytosolic Pyp gene and characterization of its functional promoter are reported.
      Title: Cloning, expression, and functional analysis of rat liver cytosolic inorganic pyrophosphatase gene and characterization of its functional promoter.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inorganic diphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate-containing compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inorganic pyrophosphatase
    Names
    pyrophosphatase (inorganic) 1
    pyrophosphatase 1
    NP_001094304.1
    XP_038954538.1
    XP_063135139.1
    XP_063135140.1
    XP_063135141.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100834.1 → NP_001094304.1  inorganic pyrophosphatase

      Status: VALIDATED

      Source sequence(s)
      BC099794
      UniProtKB/TrEMBL
      F7EPH4
      Related
      ENSRNOP00000091904.1, ENSRNOT00000107042.2
      Conserved Domains (1) summary
      cl00217
      Location:2 → 241
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      30132088..30160492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279070.1 → XP_063135140.1  inorganic pyrophosphatase isoform X3

      UniProtKB/TrEMBL
      F7EPH4

    2. XM_063279069.1 → XP_063135139.1  inorganic pyrophosphatase isoform X2

      UniProtKB/TrEMBL
      F7EPH4

    3. XM_039098610.2 → XP_038954538.1  inorganic pyrophosphatase isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUD2, F7EPH4
      Related
      ENSRNOP00000000674.7, ENSRNOT00000000674.8
      Conserved Domains (1) summary
      cl00217
      Location:2 → 263
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    4. XM_063279071.1 → XP_063135141.1  inorganic pyrophosphatase isoform X4

      UniProtKB/TrEMBL
      A0A8I6GET1, F7EPH4
    Nucleotide Protein Strain
    Heading Accession and Version

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