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    Psmg3 proteasome assembly chaperone 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361517, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Psmg3provided by RGD
    Official Full Name
    proteasome assembly chaperone 3provided by RGD
    Primary source
    RGD:2319950
    See related
    EnsemblRapid:ENSRNOG00000001273 AllianceGenome:RGD:2319950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305593
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in chaperone-mediated protein complex assembly. Predicted to be part of protein-containing complex. Orthologous to human PSMG3 (proteasome assembly chaperone 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 74.8), Brain (RPKM 73.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmg3 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19923288..19926205)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14809440..14812357)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16898999..16901945)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene mitotic arrest deficient 1 like 1 Neighboring gene uncharacterized LOC134481158 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC102546414 Neighboring gene transmembrane protein 184A Neighboring gene MAF bZIP transcription factor K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm. Wu W, et al. Genes Cells, 2018 Oct. PMID 30133132
    2. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Hirano Y, et al. Mol Cell, 2006 Dec 28. PMID 17189198
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Le Tallec B, et al. Mol Cell, 2007 Aug 17. PMID 17707236
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proteasome assembly chaperone 3
    Names
    proteasome (prosome, macropain) assembly chaperone 3
    proteasome (prosome, macropain) assembly chaperone 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399013.1 → NP_001385942.1  proteasome assembly chaperone 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1T8, D3ZIU2
      Conserved Domains (1) summary
      pfam10178
      Location:34 → 119
      PAC3; Proteasome assembly chaperone 3

    2. NM_001399014.1 → NP_001385943.1  proteasome assembly chaperone 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1T8, D3ZIU2
      Related
      ENSRNOP00000001716.4, ENSRNOT00000001716.9
      Conserved Domains (1) summary
      pfam10178
      Location:34 → 119
      PAC3; Proteasome assembly chaperone 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19923288..19926205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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