Plcb3 phospholipase C beta 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plcb3provided by RGD
Official Full Name: phospholipase C beta 3provided by RGD
Primary source: RGD:61993
See related: EnsemblRapid:ENSRNOG00000021150 AllianceGenome:RGD:61993
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phosphatidylinositol phospholipase C activity. Involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and post-Golgi vesicle-mediated transport. Located in cytosol and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (phospholipase C beta 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 97.1), Adrenal (RPKM 78.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213572499..213589585, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204143257..204160384, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222207887..222224993, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High phospholipase C beta 3 expression is associated with hypertension and cardiac hypertrophy.
Title: Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway.
Silencing of either c-Fos or c-Jun also depressed the norepinephrine-mediated increases in PLC beta(1), beta(3) and gamma(1) protein content and activity in an isozyme specific manner.
Title: Reciprocal regulation of transcription factors and PLC isozyme gene expression in adult cardiomyocytes.
Phosphorylation of Pthr1 at Ser1105 is demonstrated as a regulatory mechanism of PLCbeta3 by PKA.
Title: Negative regulation of parathyroid hormone (PTH)-activated phospholipase C by PTH/PTH-related peptide receptor phosphorylation and protein kinase A.
Shank2 brings PLC-beta3 closer to Homer 1b and constitutes an efficient mGluR-coupled signaling pathway in the PSD region of neuronal synapses
Title: The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal.

Submit: New GeneRIF Correction

General gene information

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Markers

Plcb3 (e-PCR), detects polymorphism
- UniSTS:507151

RH133323 (e-PCR)
- UniSTS:216606

RH142215 (e-PCR)
- UniSTS:231465

Plcb3 (e-PCR), detects polymorphism
- UniSTS:144220

D1Wox66 (e-PCR)
- UniSTS:239572

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phospholipase C activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol trisphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in post-Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in postsynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Names: PLC-beta-3; phosphoinositide phospholipase C-beta-3; phospholipase C, beta 3 (phosphatidylinositol-specific)

NP_203501.1

EC 3.1.4.11

XP_006230773.1

EC 3.1.4.11

XP_038962492.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033350.1 → NP_203501.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

See identical proteins and their annotated locations for NP_203501.1

Status: PROVISIONAL

Source sequence(s)

DQ120508

UniProtKB/Swiss-Prot

Q62887, Q99JE6, Q9QW29

UniProtKB/TrEMBL

F7FBZ0, Q45QJ4

Related

ENSRNOP00000028720.6, ENSRNOT00000028720.8

Conserved Domains (7) summary

cd00275
Location:729 → 844

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:316 → 694

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

cd13361
Location:22 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam02050
Location:1031 → 1103

FliJ; Flagellar FliJ protein

pfam06631
Location:952 → 989

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:1032 → 1204

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:225 → 315

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213572499..213589585 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230711.5 → XP_006230773.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1

See identical proteins and their annotated locations for XP_006230773.1

UniProtKB/Swiss-Prot

Q62887, Q99JE6, Q9QW29

UniProtKB/TrEMBL

F7FBZ0, Q45QJ4

Conserved Domains (7) summary

cd00275
Location:729 → 844

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08591
Location:316 → 694

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

cd13361
Location:22 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam02050
Location:1031 → 1103

FliJ; Flagellar FliJ protein

pfam06631
Location:952 → 989

DUF1154; Protein of unknown function (DUF1154)

pfam08703
Location:1032 → 1204

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:225 → 315

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
XM_039106564.2 → XP_038962492.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2

Conserved Domains (3) summary

cd08591
Location:316 → 682

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

cd13361
Location:22 → 149

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

cd16210
Location:154 → 304

EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)