Daxx death-domain associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Daxxprovided by RGD
Official Full Name: death-domain associated proteinprovided by RGD
Primary source: RGD:621227
See related: EnsemblRapid:ENSRNOG00000000477 AllianceGenome:RGD:621227
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables JUN kinase binding activity; kinesin binding activity; and nuclear androgen receptor binding activity. Involved in several processes, including PML body organization; cellular response to cytokine stimulus; and regulation of protein kinase activity. Located in several cellular components, including PML body; XY body; and microtubule. Used to study transient cerebral ischemia. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 92.8), Spleen (RPKM 86.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4971973..4978062, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4970090..4976145, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5480103..5485962, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings support the hypothesis that the epigenetic factors HDAC1 and DAXX are part of a complex network of genes that contribute to the synaptic regulation of GAD67 and GAD65 and help to promote the functional integrity of GABAergic interneurons located within stratum oriens-CA3/2 of the hippocampus
Title: Epigenetic Regulation of Glutamic Acid Decarboxylase 67 in a Hippocampal Circuit.
Study concluded that pre-treatment with necrostatin-1 can protect neurons in the hippocampal CA1 region against ischemic damage through the RIP3-DAXX signaling pathway.
Title: Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats.
These results provide evidence for the idea that SUMO-1-conjugated E1B-55K-mediated degradation of Daxx plays a key role in adenoviral oncogenic transformation.
Title: Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells.
Daxx and macrophage Ste20-like kinase (MST)1 mediate interferon (IFN)-gamma-induced apoptosis in microglia.
Title: Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.
Daxx overexpression protected the cells from apoptosis, while they were sensitised to cell death following its down-regulation by siRNA.
Title: Daxx inhibits stress-induced apoptosis in cardiac myocytes.
Data show that overexpression of Daxx in HepG(2) cells decreased intracellular cholesterol accumulation, which might be associated with inhibition of SREBP activity and an increase in caveolin-1 expression.
Title: Effect of Daxx on cholesterol accumulation in hepatic cells.
A rat homologue of Daxx has been isolated and cloned; study suggests that Daxx may function as a corepressor for the androgen receptor.
Title: Cloning and functional characterization of a rat Daxx that functions as a corepressor for the androgen receptor.
Upon ischemic stress, nuclear export of Daxx to the cytoplasm was observed in primary myocytes as well as in various cell lines.
Title: Subcellular localization of Daxx determines its opposing functions in ischemic cell death.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables JUN kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear androgen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription regulator inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in PML body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to copper ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to copper ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to diamide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to diamide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diamide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to sodium arsenite	IEA Inferred from Electronic Annotation more info
involved_in cellular response to sodium arsenite	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in cellular response to unfolded protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron intrinsic apoptotic signaling pathway in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in neuron intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in XY body	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: death domain-associated protein 6

Names: Fas death domain-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080891.2 → NP_543167.2 death domain-associated protein 6

See identical proteins and their annotated locations for NP_543167.2

Status: VALIDATED

Source sequence(s)

BC128729

UniProtKB/Swiss-Prot

Q8VIB2

UniProtKB/TrEMBL

A1A5M7, A6JJI8, Q6MGC8

Related

ENSRNOP00000000559.3, ENSRNOT00000000559.6

Conserved Domains (2) summary

cd13150
Location:181 → 385

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 144

Daxx; Daxx N-terminal Rassf1C-interacting domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

4971973..4978062 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256108.5 → XP_006256170.1 death domain-associated protein 6 isoform X1

See identical proteins and their annotated locations for XP_006256170.1

UniProtKB/TrEMBL

A0A0U1RRP8, A0A8I6GLP1

Conserved Domains (2) summary

cd13150
Location:181 → 385

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 146

Daxx; Daxx N-terminal Rassf1C-interacting domain
XM_006256110.5 → XP_006256172.1 death domain-associated protein 6 isoform X2

See identical proteins and their annotated locations for XP_006256172.1

UniProtKB/Swiss-Prot

Q8VIB2

UniProtKB/TrEMBL

A1A5M7, A6JJI8, Q6MGC8

Conserved Domains (2) summary

cd13150
Location:181 → 385

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 144

Daxx; Daxx N-terminal Rassf1C-interacting domain
XM_063278939.1 → XP_063135009.1 death domain-associated protein 6 isoform X1

UniProtKB/TrEMBL

A0A8I6GLP1
XM_039098392.2 → XP_038954320.1 death domain-associated protein 6 isoform X2

UniProtKB/Swiss-Prot

Q8VIB2

UniProtKB/TrEMBL

A1A5M7, A6JJI8, Q6MGC8

Conserved Domains (2) summary

cd13150
Location:181 → 385

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 144

Daxx; Daxx N-terminal Rassf1C-interacting domain
XM_063278941.1 → XP_063135011.1 death domain-associated protein 6 isoform X2

UniProtKB/TrEMBL

A1A5M7, A6JJI8, Q6MGC8
XM_006256106.5 → XP_006256168.1 death domain-associated protein 6 isoform X1

See identical proteins and their annotated locations for XP_006256168.1

UniProtKB/TrEMBL

A0A0U1RRP8, A0A8I6GLP1

Related

ENSRNOP00000096625.1, ENSRNOT00000119385.2

Conserved Domains (2) summary

cd13150
Location:181 → 385

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 146

Daxx; Daxx N-terminal Rassf1C-interacting domain
XM_063278942.1 → XP_063135012.1 death domain-associated protein 6 isoform X2

UniProtKB/TrEMBL

A1A5M7, A6JJI8, Q6MGC8
XM_006256107.5 → XP_006256169.1 death domain-associated protein 6 isoform X1

See identical proteins and their annotated locations for XP_006256169.1

UniProtKB/TrEMBL

A0A0U1RRP8, A0A8I6GLP1

Conserved Domains (2) summary

cd13150
Location:181 → 385

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 146

Daxx; Daxx N-terminal Rassf1C-interacting domain
XM_063278940.1 → XP_063135010.1 death domain-associated protein 6 isoform X1

UniProtKB/TrEMBL

A0A8I6GLP1