U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Mtpn myotrophin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79215, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mtpnprovided by RGD
    Official Full Name
    myotrophinprovided by RGD
    Primary source
    RGD:619806
    See related
    EnsemblRapid:ENSRNOG00000011857 AllianceGenome:RGD:619806
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gcdp
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to mechanical stimulus; cerebellar granule cell differentiation; and positive regulation of macromolecule metabolic process. Located in axon; cytosol; and nucleus. Used to study hypertension. Biomarker of hypertension. Orthologous to human MTPN (myotrophin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 514.8), Spleen (RPKM 475.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mtpn in Genome Data Viewer
    Location:
    4q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (65126390..65153803, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (64159273..64186686, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (63012009..63039422, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486754 Neighboring gene SPT4 homolog, DSIF elongation factor subunit, pseudogene 2 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC108675

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in catecholamine metabolic process PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cerebellar granule cell differentiation PubMed 
    involved_in neuron differentiation PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of macromolecule biosynthetic process PubMed 
    involved_in positive regulation of protein metabolic process PubMed 
    involved_in regulation of barbed-end actin filament capping  
    involved_in regulation of barbed-end actin filament capping  
    involved_in regulation of barbed-end actin filament capping  
    involved_in regulation of cell size  
    involved_in skeletal muscle tissue regeneration PubMed 
    involved_in striated muscle cell differentiation PubMed 
    Component Evidence Code Pubs
    part_of F-actin capping protein complex  
    located_in axon PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    myotrophin
    Names
    V-1 protein
    granule cell differentiation protein
    growth factor
    protein V-1
    stimulates myocyte growth

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024374.4NP_077350.1  myotrophin

      See identical proteins and their annotated locations for NP_077350.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088136
      UniProtKB/Swiss-Prot
      P62775, Q58HB3
      UniProtKB/TrEMBL
      A6IEP4
      Related
      ENSRNOP00000015808.7, ENSRNOT00000015808.9
      Conserved Domains (2) summary
      sd00045
      Location:632
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:697
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      65126390..65153803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.