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    Abcg1 ATP binding cassette subfamily G member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85264, updated on 27-Nov-2024

    Summary

    Official Symbol
    Abcg1provided by RGD
    Official Full Name
    ATP binding cassette subfamily G member 1provided by RGD
    Primary source
    RGD:620294
    See related
    EnsemblRapid:ENSRNOG00000001158 AllianceGenome:RGD:620294
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abc8
    Summary
    Predicted to enable several functions, including ABC-type sterol transporter activity; adenyl ribonucleotide binding activity; and protein dimerization activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and positive regulation of secretory granule organization. Predicted to be located in external side of plasma membrane; mitochondrion; and recycling endosome. Predicted to be active in plasma membrane. Biomarker of end stage renal disease. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 207.9), Spleen (RPKM 182.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Abcg1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9128056..9184312)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9126687..9182948)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (9743269..9842735)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uromodulin-like 1 Neighboring gene uncharacterized LOC134483780 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene trefoil factor 3 Neighboring gene trefoil factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type sterol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ABC-type sterol transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to high density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in glycoprotein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-binding cassette sub-family G member 1
    Names
    ATP-binding cassette, sub-family G (WHITE), member 1
    ATP-binding cassette, subfamily G (WHITE), member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053502.2NP_445954.2  ATP-binding cassette sub-family G member 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JJX9, G3V642, Q9EPG9
      Related
      ENSRNOP00000074901.3, ENSRNOT00000078031.3
      Conserved Domains (1) summary
      TIGR00955
      Location:60666
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      9128056..9184312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)