Rps6ka3 ribosomal protein S6 kinase A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps6ka3provided by RGD
Official Full Name: ribosomal protein S6 kinase A3provided by RGD
Primary source: RGD:1563860
See related: EnsemblRapid:ENSRNOG00000006632 AllianceGenome:RGD:1563860
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563860
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein kinase binding activity; and ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including TORC1 signaling; response to lipopolysaccharide; and toll-like receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 164.9), Muscle (RPKM 141.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (39325926..39432017, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (35517306..35623296, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (37469736..37576055)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH144512 (e-PCR)
- UniSTS:233757

A010B08 (e-PCR)
- UniSTS:20785

RH142521 (e-PCR)
- UniSTS:231768

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-3

Names: ribosomal protein S6 kinase polypeptide 3

NP_001178933.1

EC 2.7.11.1

XP_006256985.1

EC 2.7.11.1

XP_008771414.1

EC 2.7.11.1

XP_017457618.1

EC 2.7.11.1

XP_038955902.1

EC 2.7.11.1

XP_038955904.1

EC 2.7.11.1

XP_038955905.1

EC 2.7.11.1

XP_038955906.1

EC 2.7.11.1

XP_063136319.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001192004.3 → NP_001178933.1 ribosomal protein S6 kinase alpha-3

See identical proteins and their annotated locations for NP_001178933.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I6G9P7, A6IPN3, D3Z8E0

Related

ENSRNOP00000008938.5, ENSRNOT00000008938.8

Conserved Domains (2) summary

cd05582
Location:72 → 388

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:402 → 740

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

39325926..39432017 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280249.1 → XP_063136319.1 ribosomal protein S6 kinase alpha-3 isoform X2

UniProtKB/TrEMBL

A0A8I6AR08

Related

ENSRNOP00000096596.1, ENSRNOT00000110641.2
XM_017602129.3 → XP_017457618.1 ribosomal protein S6 kinase alpha-3 isoform X1

UniProtKB/TrEMBL

A0A8I6AAF4
XM_039099976.2 → XP_038955904.1 ribosomal protein S6 kinase alpha-3 isoform X4

UniProtKB/TrEMBL

A0A8I6AAF4

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_039099978.2 → XP_038955906.1 ribosomal protein S6 kinase alpha-3 isoform X4

UniProtKB/TrEMBL

A0A8I6AAF4

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_039099974.2 → XP_038955902.1 ribosomal protein S6 kinase alpha-3 isoform X3

UniProtKB/TrEMBL

A0A8I6AAF4, A0A8I6AWX9

Related

ENSRNOP00000109534.1, ENSRNOT00000171010.1

Conserved Domains (2) summary

cd05582
Location:50 → 366

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:380 → 718

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_039099977.2 → XP_038955905.1 ribosomal protein S6 kinase alpha-3 isoform X4

UniProtKB/TrEMBL

A0A8I6AAF4

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_008773192.4 → XP_008771414.1 ribosomal protein S6 kinase alpha-3 isoform X4

See identical proteins and their annotated locations for XP_008771414.1

UniProtKB/TrEMBL

A0A8I6AAF4

Related

ENSRNOP00000088908.2, ENSRNOT00000105976.2

Conserved Domains (2) summary

cd05582
Location:44 → 360

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:374 → 712

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
XM_006256923.5 → XP_006256985.1 ribosomal protein S6 kinase alpha-3 isoform X5

UniProtKB/TrEMBL

A0A8I5ZNU1, A0A8I6AAF4

Related

ENSRNOP00000079976.1, ENSRNOT00000094638.2

Conserved Domains (4) summary

smart00220
Location:39 → 298

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:43 → 359

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14176
Location:373 → 711

STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

pfam00069
Location:393 → 650

Pkinase; Protein kinase domain