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    Ephx4 epoxide hydrolase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ephx4provided by RGD
    Official Full Name
    epoxide hydrolase 4provided by RGD
    Primary source
    RGD:1308891
    See related
    EnsemblRapid:ENSRNOG00000023389 AllianceGenome:RGD:1308891
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abhd7
    Summary
    Predicted to enable hydrolase activity. Predicted to be located in membrane. Orthologous to human EPHX4 (epoxide hydrolase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 66.9), Thymus (RPKM 7.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ephx4 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (2488282..2517558, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (2343376..2372680, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (3360680..3389996, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene BTB domain containing 8 Neighboring gene uncharacterized LOC108352691 Neighboring gene lysophosphatidylcholine acyltransferase 2b Neighboring gene uncharacterized LOC108352690 Neighboring gene bromodomain testis associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epoxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epoxide hydrolase 4
    Names
    abhydrolase domain containing 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105994.1 → NP_001099464.1  epoxide hydrolase 4

      See identical proteins and their annotated locations for NP_001099464.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474079
      UniProtKB/TrEMBL
      A6KPJ6
      Conserved Domains (1) summary
      COG0596
      Location:1 → 260
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      2488282..2517558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769927.4 → XP_008768149.2  epoxide hydrolase 4 isoform X1

      UniProtKB/TrEMBL
      A6KPJ6
      Related
      ENSRNOP00000083130.2, ENSRNOT00000100966.2
      Conserved Domains (1) summary
      COG0596
      Location:1 → 260
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    2. XM_039091658.2 → XP_038947586.1  epoxide hydrolase 4 isoform X1

      UniProtKB/TrEMBL
      A6KPJ6
      Conserved Domains (1) summary
      COG0596
      Location:1 → 260
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    3. XM_039091659.2 → XP_038947587.1  epoxide hydrolase 4 isoform X2

      Conserved Domains (1) summary
      pfam00561
      Location:92 → 209
      Abhydrolase_1; alpha/beta hydrolase fold
    Nucleotide Protein Strain
    Heading Accession and Version

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