Dct dopachrome tautomerase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dctprovided by RGD
Official Full Name: dopachrome tautomeraseprovided by RGD
Primary source: RGD:1564975
See related: EnsemblRapid:ENSRNOG00000008671 AllianceGenome:RGD:1564975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564975
Summary: Predicted to enable dopachrome isomerase activity. Predicted to be involved in melanin biosynthetic process from tyrosine and response to blue light. Predicted to act upstream of or within several processes, including melanin biosynthetic process; positive regulation of neuroblast proliferation; and ventricular zone neuroblast division. Predicted to be located in cytosol; melanosome; and plasma membrane. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 6.1), Spleen (RPKM 5.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (101469159..101508029, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (95062006..95100863, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (103208174..103245033, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dopachrome isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopachrome isomerase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
involved_in developmental pigmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within developmental pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in melanin biosynthetic process from tyrosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanin biosynthetic process from tyrosine	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to blue light	ISO Inferred from Sequence Orthology more info
involved_in ventricular zone neuroblast division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular zone neuroblast division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: L-dopachrome tautomerase

Names: dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

NP_001414197.1

EC 5.3.3.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.