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    Sgsm1 small G protein signaling modulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgsm1provided by RGD
    Official Full Name
    small G protein signaling modulator 1provided by RGD
    Primary source
    RGD:1308178
    See related
    EnsemblRapid:ENSRNOG00000000708 AllianceGenome:RGD:1308178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rutbc2
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasmic vesicle membrane and cytosol. Orthologous to human SGSM1 (small G protein signaling modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 83.9), Kidney (RPKM 13.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgsm1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48969578..49049110)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (43320500..43386469)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (49329093..49395078)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene WSC domain containing 2 Neighboring gene uncharacterized LOC108352468 Neighboring gene uncharacterized LOC102551333 Neighboring gene uncharacterized LOC108352469 Neighboring gene uncharacterized LOC134481308 Neighboring gene uncharacterized LOC134481307 Neighboring gene uncharacterized LOC108352470 Neighboring gene uncharacterized LOC134481210 Neighboring gene LHFPL tetraspan subfamily member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. Nottingham RM, et al. J Biol Chem, 2012 Jun 29. PMID 22637480, Free PMC Article
    2. Identification of a novel nurr1-interacting protein. Luo Y, et al. J Neurosci, 2008 Sep 10. PMID 18784308, Free PMC Article
    3. Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2. Zhang Z, et al. Structure, 2014 Oct 7. PMID 25220469
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small G protein signaling modulator 1
    Names
    RUN and TBC1 domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105937.2 → NP_001099407.2  small G protein signaling modulator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I5ZYM5
      Related
      ENSRNOP00000084191.2, ENSRNOT00000094880.2
      Conserved Domains (3) summary
      smart00164
      Location:881 → 1050
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:254 → 425
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:44 → 186
      RUN; RUN domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      48969578..49049110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089276.2 → XP_038945204.1  small G protein signaling modulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYM5, D3ZAS2
      Conserved Domains (3) summary
      smart00164
      Location:884 → 1053
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:257 → 428
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:44 → 186
      RUN; RUN domain

    2. XM_063271225.1 → XP_063127295.1  small G protein signaling modulator 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZYM5, A0A8I6A6E1
      Related
      ENSRNOP00000086971.1, ENSRNOT00000106588.2

    3. XM_063271224.1 → XP_063127294.1  small G protein signaling modulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYM5

    4. XM_063271223.1 → XP_063127293.1  small G protein signaling modulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYM5, D3ZAS2

    5. XM_063271222.1 → XP_063127292.1  small G protein signaling modulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYM5, D3ZAS2

    6. XM_039089280.2 → XP_038945208.1  small G protein signaling modulator 1 isoform X3

      Conserved Domains (1) summary
      smart00164
      Location:461 → 630
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein Strain
    Heading Accession and Version

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