Stap1 signal transducing adaptor family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stap1provided by RGD
Official Full Name: signal transducing adaptor family member 1provided by RGD
Primary source: RGD:1311584
See related: EnsemblRapid:ENSRNOG00000002014 AllianceGenome:RGD:1311584
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stap-1; RGD1311584
Summary: Predicted to enable phosphotyrosine residue binding activity; protein tyrosine kinase activator activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of macrophage migration; negative regulation of ruffle assembly; and regulation of signal transduction. Predicted to act upstream of or within response to bacterium. Predicted to be located in several cellular components, including centriolar satellite; mitochondrion; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human STAP1 (signal transducing adaptor family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 229.8), Thymus (RPKM 111.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (22301278..22336218, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (21950466..21981395, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (23575400..23604984, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables macrophage colony-stimulating factor receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microglial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal-transducing adaptor protein 1

Names: stem cell adaptor protein STAP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025115.1 → NP_001020286.1 signal-transducing adaptor protein 1

See identical proteins and their annotated locations for NP_001020286.1

Status: PROVISIONAL

Source sequence(s)

BC091249

UniProtKB/TrEMBL

A0A8I6ACF3, Q5BK11

Related

ENSRNOP00000002760.5, ENSRNOT00000002760.7

Conserved Domains (2) summary

cd10403
Location:178 → 271

SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)

cl17171
Location:15 → 139

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

22301278..22336218 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599182.3 → XP_017454671.1 signal-transducing adaptor protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZSB1, A6JCR9

Related

ENSRNOP00000081110.1, ENSRNOT00000096289.2
XM_006250812.4 → XP_006250874.1 signal-transducing adaptor protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ACF3

Related

ENSRNOP00000110149.1, ENSRNOT00000126926.1

Conserved Domains (2) summary

cd10403
Location:178 → 271

SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)

cl17171
Location:15 → 139

PH-like; Pleckstrin homology-like domain
XM_017599181.2 → XP_017454670.1 signal-transducing adaptor protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6ACF3