Card14 caspase recruitment domain family, member 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Card14provided by RGD
Official Full Name: caspase recruitment domain family, member 14provided by RGD
Primary source: RGD:1591135
See related: EnsemblRapid:ENSRNOG00000047367 AllianceGenome:RGD:1591135
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CARD domain binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in aggresome and cytosol. Human ortholog(s) of this gene implicated in pityriasis rubra pilaris and psoriasis 2. Orthologous to human CARD14 (caspase recruitment domain family member 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 20.6), Kidney (RPKM 17.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (105064941..105100132)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (104572059..104601606)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (108440480..108469012)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU027129 (e-PCR)
- UniSTS:113607

D10Rat109 (e-PCR), detects polymorphism
- UniSTS:226272

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CARD domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase recruitment domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427162.1 → NP_001414091.1 caspase recruitment domain-containing protein 14

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

M0R6R8

Related

ENSRNOP00000082528.2, ENSRNOT00000108977.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

105064941..105100132

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087525.2 → XP_038943453.2 caspase recruitment domain-containing protein 14 isoform X6
XM_039087526.2 → XP_038943454.2 caspase recruitment domain-containing protein 14 isoform X7
XM_039087528.2 → XP_038943456.1 caspase recruitment domain-containing protein 14 isoform X8

UniProtKB/TrEMBL

A6HL81

Conserved Domains (4) summary

cd00992
Location:601 → 673

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:135 → 430

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:698 → 759

SH3; Src Homology 3 domain superfamily
XM_039087521.2 → XP_038943449.1 caspase recruitment domain-containing protein 14 isoform X2

UniProtKB/TrEMBL

A6HL81

Conserved Domains (5) summary

cd00992
Location:600 → 672

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:135 → 430

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:697 → 758

SH3; Src Homology 3 domain superfamily

cl17190
Location:897 → 1004

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039087519.2 → XP_038943447.1 caspase recruitment domain-containing protein 14 isoform X1

UniProtKB/TrEMBL

A6HL81

Conserved Domains (5) summary

cd00992
Location:601 → 673

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:135 → 430

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:698 → 759

SH3; Src Homology 3 domain superfamily

cl17190
Location:898 → 1005

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039087520.2 → XP_038943448.1 caspase recruitment domain-containing protein 14 isoform X1

UniProtKB/TrEMBL

A6HL81

Conserved Domains (5) summary

cd00992
Location:601 → 673

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:135 → 430

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:698 → 759

SH3; Src Homology 3 domain superfamily

cl17190
Location:898 → 1005

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039087523.2 → XP_038943451.1 caspase recruitment domain-containing protein 14 isoform X4

UniProtKB/TrEMBL

A6HL81

Related

ENSRNOP00000065123.4, ENSRNOT00000070842.4

Conserved Domains (5) summary

cd00992
Location:601 → 673

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:135 → 430

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:698 → 759

SH3; Src Homology 3 domain superfamily

cl17190
Location:875 → 982

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039087522.2 → XP_038943450.1 caspase recruitment domain-containing protein 14 isoform X3

UniProtKB/TrEMBL

A0A8I5ZU45, A6HL81

Conserved Domains (5) summary

cd00992
Location:580 → 652

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:135 → 409

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl14633
Location:19 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl17036
Location:677 → 738

SH3; Src Homology 3 domain superfamily

cl17190
Location:877 → 984

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039087524.2 → XP_038943452.1 caspase recruitment domain-containing protein 14 isoform X5

UniProtKB/TrEMBL

A6HL81

Conserved Domains (4) summary

cd00992
Location:483 → 555

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:17 → 312

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17036
Location:580 → 641

SH3; Src Homology 3 domain superfamily

cl17190
Location:780 → 887

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...