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    Invs inversin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Invsprovided by RGD
    Official Full Name
    inversinprovided by RGD
    Primary source
    RGD:1563359
    See related
    EnsemblRapid:ENSRNOG00000008632 AllianceGenome:RGD:1563359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563359
    Summary
    Predicted to be involved in kidney development; negative regulation of canonical Wnt signaling pathway; and protein localization to ciliary inversin compartment. Predicted to act upstream of or within several processes, including left/right pattern formation; pancreas development; and protein phosphorylation. Predicted to be located in ciliary base and ciliary inversin compartment. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in hypertension and nephronophthisis 2. Orthologous to human INVS (inversin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 39.4), Lung (RPKM 31.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Invs in Genome Data Viewer
    Location:
    5q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (67406511..67559355)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (62610916..62763813)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (64031131..64180830)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene syntaxin 17 Neighboring gene exosome component 8, pseudogene 1 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene uncharacterized LOC102551711 Neighboring gene testis expressed 10 Neighboring gene uncharacterized LOC108350968 Neighboring gene Myb/SANT DNA binding domain containing 3 Neighboring gene transmembrane protein with EGF-like and two follistatin-like domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules. Li L, et al. Endocrinology, 2022 Apr 1. PMID 35106541, Free PMC Article
    2. Multiple renal cyst development but not situs abnormalities in transgenic RNAi mice against Inv::GFP rescue gene. Kamijho Y, et al. PLoS One, 2014. PMID 24586938, Free PMC Article
    3. Sustained cell proliferation of renal epithelial cells in mice with inv mutation. Sugiyama N, et al. Genes Cells, 2006 Oct. PMID 16999740
    4. Anomalous development of the hepatobiliary system in the Inv mouse. Mazziotti MV, et al. Hepatology, 1999 Aug. PMID 10421642
    5. Mutations of NPHP2 and NPHP3 in infantile nephronophthisis. Tory K, et al. Kidney Int, 2009 Apr. PMID 19177160

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules.
      Title: PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within animal organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic heart tube left/right pattern formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to ciliary inversin compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to ciliary inversin compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary inversin compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inversin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107932.2 → NP_001101402.1  inversin

      See identical proteins and their annotated locations for NP_001101402.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6KJF5, D4A4A8
      Related
      ENSRNOP00000107064.1, ENSRNOT00000161508.1
      Conserved Domains (4) summary
      cd00204
      Location:384 → 509
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:427 → 517
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:356 → 387
      ANK; ANK repeat [structural motif]
      cl00936
      Location:628 → 816
      RecX; RecX family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      67406511..67559355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109855.2 → XP_038965783.1  inversin isoform X1

      Related
      ENSRNOP00000011622.9, ENSRNOT00000011622.9
      Conserved Domains (6) summary
      PHA02874
      Location:62 → 262
      PHA02874; ankyrin repeat protein; Provisional
      PHA03307
      Location:634 → 899
      PHA03307; transcriptional regulator ICP4; Provisional
      COG0666
      Location:252 → 400
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:378 → 409
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:33 → 88
      Ank_5; Ankyrin repeats (many copies)
      cl39094
      Location:358 → 576
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_039109856.2 → XP_038965784.1  inversin isoform X2

      Conserved Domains (6) summary
      PHA02874
      Location:62 → 262
      PHA02874; ankyrin repeat protein; Provisional
      COG0666
      Location:252 → 400
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:378 → 409
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:33 → 88
      Ank_5; Ankyrin repeats (many copies)
      NF033838
      Location:617 → 710
      PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
      cl39094
      Location:358 → 576
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_039109857.2 → XP_038965785.1  inversin isoform X3

      Conserved Domains (6) summary
      PHA02874
      Location:62 → 262
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:356 → 387
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:225 → 311
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:33 → 88
      Ank_5; Ankyrin repeats (many copies)
      NF033838
      Location:595 → 688
      PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
      cl39094
      Location:336 → 554
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_039109860.2 → XP_038965788.1  inversin isoform X4

      Conserved Domains (5) summary
      PHA02874
      Location:62 → 262
      PHA02874; ankyrin repeat protein; Provisional
      COG0666
      Location:252 → 400
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:378 → 409
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:33 → 88
      Ank_5; Ankyrin repeats (many copies)
      cl39094
      Location:358 → 576
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_039109859.2 → XP_038965787.1  inversin isoform X4

      Conserved Domains (5) summary
      PHA02874
      Location:62 → 262
      PHA02874; ankyrin repeat protein; Provisional
      COG0666
      Location:252 → 400
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:378 → 409
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:33 → 88
      Ank_5; Ankyrin repeats (many copies)
      cl39094
      Location:358 → 576
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_063287624.1 → XP_063143694.1  inversin isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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