Rbm11 RNA binding motif protein 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbm11provided by RGD
Official Full Name: RNA binding motif protein 11provided by RGD
Primary source: RGD:1305195
See related: EnsemblRapid:ENSRNOG00000029147 AllianceGenome:RGD:1305195
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable poly(U) RNA binding activity and protein homodimerization activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within cellular response to oxidative stress. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human RBM11 (RNA binding motif protein 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 23.3), Testes (RPKM 13.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (27721870..27731125)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (14234851..14244092)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (14005704..14015723)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: splicing regulator RBM11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401847.1 → NP_001388776.1 splicing regulator RBM11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

Related

ENSRNOP00000046624.7, ENSRNOT00000047240.7

Conserved Domains (1) summary

cd12593
Location:9 → 83

RRM_RBM11; RNA recognition motif (RRM) found in vertebrate RNA-binding protein 11 (RBM11)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

27721870..27731125

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247995.5 → XP_006248057.1 splicing regulator RBM11 isoform X1

Conserved Domains (2) summary

COG0724
Location:1 → 139

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12593
Location:9 → 83

RRM_RBM11; RNA recognition motif in vertebrate RNA-binding protein 11 (RBM11)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001105898.1: Suppressed sequence

Description

NM_001105898.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.