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    Tbl1x transducin (beta)-like 1 X-linked [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302711, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tbl1xprovided by RGD
    Official Full Name
    transducin (beta)-like 1 X-linkedprovided by RGD
    Primary source
    RGD:1563868
    See related
    EnsemblRapid:ENSRNOG00000003686 AllianceGenome:RGD:1563868
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563868
    Summary
    Predicted to enable several functions, including histone binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; protein stabilization; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including fat cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to estrogen. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Human ortholog(s) of this gene implicated in Y-linked deafness 2 and congenital nongoitrous hypothyroidism 8. Orthologous to several human genes including TBL1X (transducin beta like 1 X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 210.3), Thymus (RPKM 155.0) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbl1x in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (45452983..45609532)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (41574558..41731117)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (44959883..44988551)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene YKT6 v-SNARE like 1 Neighboring gene ferritin light chain 1, pseudogene 13 Neighboring gene claudin 34E Neighboring gene BCL2 interacting protein 3, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. Bassi MT, et al. Am J Hum Genet, 1999 Jun. PMID 10330347, Free PMC Article
    2. Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Oberoi J, et al. Nat Struct Mol Biol, 2011 Feb. PMID 21240272, Free PMC Article
    3. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Perissi V, et al. Mol Cell, 2008 Mar 28. PMID 18374649, Free PMC Article
    4. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Guenther MG, et al. Genes Dev, 2000 May 1. PMID 10809664, Free PMC Article
    5. TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Li J, et al. Nat Cell Biol, 2008 Feb. PMID 18193033

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to steroid hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box-like/WD repeat-containing protein TBL1X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106964.1 → NP_001100434.1  F-box-like/WD repeat-containing protein TBL1X

      See identical proteins and their annotated locations for NP_001100434.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473966
      UniProtKB/TrEMBL
      A0A0G2JY80, A6IPS7, G3V6G5
      Conserved Domains (3) summary
      cd00200
      Location:177 → 483
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:185 → 232
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      45452983..45609532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099666.2 → XP_038955594.1  F-box-like/WD repeat-containing protein TBL1X isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY80, A6IPS7, G3V6G5
      Conserved Domains (3) summary
      cd00200
      Location:177 → 483
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:185 → 232
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH

    2. XM_039099665.2 → XP_038955593.1  F-box-like/WD repeat-containing protein TBL1X isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY80, A6IPS7, G3V6G5
      Related
      ENSRNOP00000070551.1, ENSRNOT00000079680.3
      Conserved Domains (3) summary
      cd00200
      Location:177 → 483
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:185 → 232
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:7 → 31
      LisH
    Nucleotide Protein Strain
    Heading Accession and Version

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