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    Acot9 acyl-CoA thioesterase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302640, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Acot9provided by RGD
    Official Full Name
    acyl-CoA thioesterase 9provided by RGD
    Primary source
    RGD:1359188
    See related
    EnsemblRapid:ENSRNOG00000003782 AllianceGenome:RGD:1359188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acate2
    Summary
    Predicted to enable acetyl-CoA hydrolase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and short-chain fatty acid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 264.7), Heart (RPKM 225.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acot9 in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (43922943..43973311, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (40073197..40123573, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (43543069..43592200, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 4 Neighboring gene E3 ubiquitin-protein ligase RNF168-like Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene spermidine/spermine N1-acetyl transferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. Poupon V, et al. J Biol Chem, 1999 Jul 2. PMID 10383425
    2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. Hunt MC, et al. J Lipid Res, 2005 Sep. PMID 16103133
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in short-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-coenzyme A thioesterase 9, mitochondrial
    Names
    acyl-Coenzyme A thioesterase 2, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013960.1 → NP_001013982.1  acyl-coenzyme A thioesterase 9, mitochondrial

      See identical proteins and their annotated locations for NP_001013982.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085822
      UniProtKB/TrEMBL
      F7ETS0, Q5U2X8
      Related
      ENSRNOP00000005033.5, ENSRNOT00000005033.7
      Conserved Domains (1) summary
      cd03442
      Location:286 → 406
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      43922943..43973311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099645.2 → XP_038955573.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6IPR3, F7ETS0
      Conserved Domains (1) summary
      PLN02647
      Location:3 → 336
      PLN02647; acyl-CoA thioesterase

    2. XM_039099644.2 → XP_038955572.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6IPR3, F7ETS0
      Conserved Domains (1) summary
      PLN02647
      Location:3 → 336
      PLN02647; acyl-CoA thioesterase
    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
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