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    Frmpd1 FERM and PDZ domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frmpd1provided by RGD
    Official Full Name
    FERM and PDZ domain containing 1provided by RGD
    Primary source
    RGD:1305229
    See related
    EnsemblRapid:ENSRNOG00000012546 AllianceGenome:RGD:1305229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in establishment of protein localization to membrane and regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cytoskeleton and glutamatergic synapse. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Predicted to colocalize with cell cortex. Orthologous to human FRMPD1 (FERM and PDZ domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 13.7), Testes (RPKM 5.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frmpd1 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64238730..64340778)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (59443076..59545125)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60735413..60837773)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L24-like Neighboring gene uncharacterized LOC120103148 Neighboring gene uncharacterized LOC120102864 Neighboring gene tRNA methyltransferase 10B Neighboring gene uncharacterized LOC134486935 Neighboring gene exosome component 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Samuelson DJ, et al. Proc Natl Acad Sci U S A, 2007 Apr 10. PMID 17404222, Free PMC Article
    2. The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. An N, et al. J Biol Chem, 2008 Sep 5. PMID 18566450, Free PMC Article
    3. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Yuzawa S, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22074847, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins.
      Title: The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in establishment of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FERM and PDZ domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107937.2 → NP_001101407.2  FERM and PDZ domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      BQ201883, JAXUCZ010000005
      UniProtKB/TrEMBL
      D3ZW88
      Related
      ENSRNOP00000016839.7, ENSRNOT00000016839.9
      Conserved Domains (5) summary
      smart00295
      Location:182 → 401
      B41; Band 4.1 homologues
      cd00992
      Location:56 → 132
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:397 → 501
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17168
      Location:179 → 268
      FERM_F1_FRMPD1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 1 (FRMPD1)
      pfam15961
      Location:1125 → 1257
      DUF4764; Domain of unknown function (DUF4764)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      64238730..64340778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287631.1 → XP_063143701.1  FERM and PDZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZW88

    2. XM_008763690.4 → XP_008761912.1  FERM and PDZ domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008761912.1

      UniProtKB/TrEMBL
      D3ZW88
      Conserved Domains (5) summary
      smart00295
      Location:182 → 401
      B41; Band 4.1 homologues
      cd00992
      Location:56 → 132
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:397 → 501
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17168
      Location:179 → 268
      FERM_F1_FRMPD1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 1 (FRMPD1)
      pfam15961
      Location:1125 → 1257
      DUF4764; Domain of unknown function (DUF4764)
    Nucleotide Protein Strain
    Heading Accession and Version

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