Adgrb1 adhesion G protein-coupled receptor B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adgrb1provided by RGD
Official Full Name: adhesion G protein-coupled receptor B1provided by RGD
Primary source: RGD:1305608
See related: EnsemblRapid:ENSRNOG00000029450 AllianceGenome:RGD:1305608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bai1
Summary: Predicted to enable several functions, including PDZ domain binding activity; lipopolysaccharide binding activity; and phosphatidylserine binding activity. Involved in postsynaptic actin cytoskeleton organization. Is active in glutamatergic synapse and postsynaptic membrane. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human ADGRB1 (adhesion G protein-coupled receptor B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 170.1) and Uterus (RPKM 7.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (108293681..108365892)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (106404827..106476902)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (115766484..115828514)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in engulfment of apoptotic cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in engulfment of apoptotic cell	IEA Inferred from Electronic Annotation more info
involved_in engulfment of apoptotic cell	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, recognition	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: adhesion G protein-coupled receptor B1

Names: brain-specific angiogenesis inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170597.3 → NP_001164068.2 adhesion G protein-coupled receptor B1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

C0HL12

UniProtKB/TrEMBL

A0A8I5ZZU7

Conserved Domains (6) summary

smart00303
Location:876 → 934

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:573 → 639

HormR; Domain present in hormone receptors

smart00209
Location:408 → 458

TSP1; Thrombospondin type 1 repeats

cd15251
Location:941 → 1197

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:657 → 855

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

pfam19188
Location:43 → 216

AGRB_N; Adhesion GPCR B N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

108293681..108365892

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263862.1 → XP_063119932.1 adhesion G protein-coupled receptor B1 isoform X7
XM_063263857.1 → XP_063119927.1 adhesion G protein-coupled receptor B1 isoform X1
XM_039079532.2 → XP_038935460.1 adhesion G protein-coupled receptor B1 isoform X2

UniProtKB/TrEMBL

A0A8I5Y6L4, A0A8I5ZZU7

Related

ENSRNOP00000077654.1, ENSRNOT00000076127.4

Conserved Domains (6) summary

smart00303
Location:873 → 931

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:570 → 636

HormR; Domain present in hormone receptors

smart00209
Location:408 → 458

TSP1; Thrombospondin type 1 repeats

cd15251
Location:938 → 1227

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:654 → 852

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

pfam19188
Location:43 → 216

AGRB_N; Adhesion GPCR B N-terminal region
XM_063263858.1 → XP_063119928.1 adhesion G protein-coupled receptor B1 isoform X3
XM_063263859.1 → XP_063119929.1 adhesion G protein-coupled receptor B1 isoform X4
XM_063263861.1 → XP_063119931.1 adhesion G protein-coupled receptor B1 isoform X6

Related

ENSRNOP00000096011.2, ENSRNOT00000076380.3
XM_063263860.1 → XP_063119930.1 adhesion G protein-coupled receptor B1 isoform X5

UniProtKB/Swiss-Prot

C0HL12
XM_063263864.1 → XP_063119934.1 adhesion G protein-coupled receptor B1 isoform X8
XM_063263867.1 → XP_063119937.1 adhesion G protein-coupled receptor B1 isoform X10
XM_063263869.1 → XP_063119939.1 adhesion G protein-coupled receptor B1 isoform X11

UniProtKB/TrEMBL

A0A8I6ASL1
XM_063263863.1 → XP_063119933.1 adhesion G protein-coupled receptor B1 isoform X8
XM_063263865.1 → XP_063119935.1 adhesion G protein-coupled receptor B1 isoform X9
XM_063263866.1 → XP_063119936.1 adhesion G protein-coupled receptor B1 isoform X10
XM_063263868.1 → XP_063119938.1 adhesion G protein-coupled receptor B1 isoform X11

UniProtKB/TrEMBL

A0A8I6ASL1