Polr1e RNA polymerase I subunit E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Polr1eprovided by RGD
Official Full Name: RNA polymerase I subunit Eprovided by RGD
Primary source: RGD:1565773
See related: EnsemblRapid:ENSRNOG00000012664 AllianceGenome:RGD:1565773
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Praf1; RGD1565773
Summary: Predicted to enable RNA polymerase I general transcription initiation factor binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and transcription elongation by RNA polymerase I. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of RNA polymerase I complex. Orthologous to human POLR1E (RNA polymerase I subunit E). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 44.2), Spleen (RPKM 39.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (64075123..64090900)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (59279456..59295346)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (60572573..60588097)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I general transcription initiation factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA polymerase I preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within RNA polymerase I preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in nucleolar large rRNA transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase I promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I complex	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA-directed RNA polymerase I subunit RPA49

Names: polymerase (RNA) I associated factor 1; polymerase (RNA) I polypeptide E; polymerase (RNA) I subunit E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107938.1 → NP_001101408.1 DNA-directed RNA polymerase I subunit RPA49

See identical proteins and their annotated locations for NP_001101408.1

Status: PROVISIONAL

Source sequence(s)

CH473962

UniProtKB/TrEMBL

A0A1B0GWN1, A0A8I6AL91, A0A9K3Y7A9, B0BN64

Related

ENSRNOP00000075957.2, ENSRNOT00000092958.3

Conserved Domains (1) summary

pfam06870
Location:51 → 427

RNA_pol_I_A49; A49-like RNA polymerase I associated factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

64075123..64090900

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109871.2 → XP_038965799.1 DNA-directed RNA polymerase I subunit RPA49 isoform X1

UniProtKB/TrEMBL

F7ESP7

Related

ENSRNOP00000094559.2, ENSRNOT00000092827.3

Conserved Domains (1) summary

pfam06870
Location:1 → 257

RNA_pol_I_A49; A49-like RNA polymerase I associated factor