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    Smim14 small integral membrane protein 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smim14provided by RGD
    Official Full Name
    small integral membrane protein 14provided by RGD
    Primary source
    RGD:1311122
    See related
    EnsemblRapid:ENSRNOG00000066377 AllianceGenome:RGD:1311122
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311122
    Summary
    Predicted to act upstream of or within blastocyst hatching. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SMIM14 (small integral membrane protein 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 277.4), Adrenal (RPKM 272.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smim14 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43136754..43180622)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42783361..42829762)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44413636..44460044)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene PDS5 cohesin associated factor A Neighboring gene ribosomal protein L14 like 2 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene lipoic acid synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein. Jun MH, et al. BMB Rep, 2014 Oct. PMID 24499674, Free PMC Article
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116420

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 14
    Names
    uncharacterized protein C4orf34 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037792.1 → NP_001032881.1  small integral membrane protein 14

      See identical proteins and their annotated locations for NP_001032881.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100271
      UniProtKB/Swiss-Prot
      Q498C7
      UniProtKB/TrEMBL
      A6JDD7
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      43136754..43180622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273436.1 → XP_063129506.1  small integral membrane protein 14 isoform X1

      UniProtKB/Swiss-Prot
      Q498C7
      UniProtKB/TrEMBL
      A6JDD7

    2. XM_063273434.1 → XP_063129504.1  small integral membrane protein 14 isoform X1

      UniProtKB/Swiss-Prot
      Q498C7
      UniProtKB/TrEMBL
      A6JDD7
      Related
      ENSRNOP00000100233.1, ENSRNOT00000137439.1

    3. XM_063273438.1 → XP_063129508.1  small integral membrane protein 14 isoform X2

    4. XM_039092247.2 → XP_038948175.1  small integral membrane protein 14 isoform X1

      UniProtKB/Swiss-Prot
      Q498C7
      UniProtKB/TrEMBL
      A6JDD7
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    5. XM_039092250.2 → XP_038948178.1  small integral membrane protein 14 isoform X1

      UniProtKB/Swiss-Prot
      Q498C7
      UniProtKB/TrEMBL
      A6JDD7
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    6. XM_039092248.2 → XP_038948176.1  small integral membrane protein 14 isoform X1

      UniProtKB/Swiss-Prot
      Q498C7
      UniProtKB/TrEMBL
      A6JDD7
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    7. XM_039092249.2 → XP_038948177.1  small integral membrane protein 14 isoform X1

      UniProtKB/Swiss-Prot
      Q498C7
      UniProtKB/TrEMBL
      A6JDD7
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    8. XM_006250961.5 → XP_006251023.1  small integral membrane protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006251023.1

      UniProtKB/Swiss-Prot
      Q498C7
      UniProtKB/TrEMBL
      A6JDD7
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    9. XM_063273437.1 → XP_063129507.1  small integral membrane protein 14 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q498C7.1 GenPept UniProtKB/Swiss-Prot:Q498C7

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