Marcks myristoylated alanine rich protein kinase C substrate [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Marcksprovided by RGD
Full Name: myristoylated alanine rich protein kinase C substrateprovided by RGD
Primary source: RGD:3028
See related: EnsemblRapid:ENSRNOG00000000579 AllianceGenome:RGD:3028
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KINC; Macs
Summary: Enables phosphatidylserine binding activity. Involved in several processes, including activation of phospholipase D activity; positive regulation of protein kinase C activity; and regulation of synapse organization. Located in several cellular components, including dendrite; distal axon; and polymeric cytoskeletal fiber. Is active in several cellular components, including postsynaptic cytoskeleton; presynaptic cytosol; and synaptic membrane. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 776.1), Spleen (RPKM 725.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (42240185..42245882, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (40685315..40691012, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (42966140..42971838)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that MARCKS is involved in oligodendrocyte precursor cell maturation by interacting with Ras-associated protein 10
Title: MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation.
Either genetic silencing of MARCKS or disruption of its interaction with Rab10 inhibited axon growth of cortical neurons.
Title: MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development.
decreased MARCKS and pMARCKS in the frontal cortex in schizophrenia was found; results suggest a mechanism other than myristoylation was responsible for decreased MARCKS expression in schizophrenia
Title: Alterations of the myristoylated, alanine-rich C kinase substrate (MARCKS) in prefrontal cortex in schizophrenia.
In spermatozoa, as in chromatoid body, BASP1 and MARCKS may bind Ca(2+)-calmodulin and therefore contribute to the activation of calcium-dependent biochemical processes.
Title: Immunoelectron microscopic study of BASP1 and MARCKS location in the early and late rat spermatids.
MARCKS phosphorylation via the activation of PKCdelta, which is downstream of PKA activation, is involved in the cAMP-dependent amylase release in parotid acinar cells.
Title: Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells.
These findings demonstrate a critical role for MARCKS-phosphatidylinositol-4,5-diphosphate signaling in regulating dendrite development.
Title: Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching.
NMDA-induced dendritic spine collapse involves cathepsin B-like proteolysis of MARCKS
Title: Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines.
Prion proteins are isolated from neuronal cells, along with Marcks and fyn.
Title: Immunoseparation of Prion protein-enriched domains from other detergent-resistant membrane fractions, isolated from neuronal cells.
These results suggest that intact phosphorylation sites within the MARCKS ED are required for PLD activation and influence both membrane-cytoskeletal organization and cell viability.
Title: Expression of MARCKS effector domain mutants alters phospholipase D activity and cytoskeletal morphology of SK-N-MC neuroblastoma cells.
These results suggest that MARCKS is a target of PKG, and PKG-dependent phosphorylation of MARCKS results in its degradation to reduce its protein levels in the cells.
Title: cGMP-dependent phosphorylation and degradation of myristoylated alanine-rich C-kinase substrate.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA901167 (e-PCR)
- UniSTS:249124

AW521654 (e-PCR)
- UniSTS:249721

RH140037 (e-PCR)
- UniSTS:222119

RH94756 (e-PCR)
- UniSTS:120003

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IEA Inferred from Electronic Annotation more info
involved_in actin crosslink formation	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in neural tube development	IEA Inferred from Electronic Annotation more info
involved_in neural tube development	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase C activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament bundle	IEA Inferred from Electronic Annotation more info
located_in actin filament bundle	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in bleb	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromatoid body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic branch	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in germinal vesicle	IEA Inferred from Electronic Annotation more info
located_in germinal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in organelle	ISO Inferred from Sequence Orthology more info
located_in outer dense fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myristoylated alanine-rich C-kinase substrate

Names: Myristoylated alanine-rich protein kinase C substrate; protein kinase C substrate 80 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271090.3 → NP_001258019.2 myristoylated alanine-rich C-kinase substrate

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P20468, P30009

UniProtKB/TrEMBL

F1LMW7

Related

ENSRNOP00000000707.7, ENSRNOT00000000707.8

Conserved Domains (1) summary

pfam02063
Location:2 → 305

MARCKS; MARCKS family