Pgp phosphoglycolate phosphatase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pgpprovided by RGD
Official Full Name: phosphoglycolate phosphataseprovided by RGD
Primary source: RGD:1307773
See related: AllianceGenome:RGD:1307773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AUM; G3PP; RGD1307773
Summary: Enables glycerol-3-phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PGP (phosphoglycolate phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 423.7), Muscle (RPKM 319.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (13999782..14002408)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13495232..13497858)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13836105..13838731)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo overexpression of PGP (functioning as glycerol-3-phosphate phosphatase) in rat liver lowers body weight gain and hepatic glucose production from glycerol and elevates plasma HDL levels. It is expressed in different tissues and nutritional states.
Title: Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH98228 (e-PCR)
- UniSTS:91450

RH127723 (e-PCR)
- UniSTS:211033

AI481330 (e-PCR)
- UniSTS:160626

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables glycerol-1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycerol-3-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycolate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycolate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in glycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerophospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerophospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glycerol-3-phosphate phosphatase

Names: aspartate-based ubiquitous Mg(2+)-dependent phosphatase

NP_001162623.1

EC 3.1.3.21

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169152.1 → NP_001162623.1 glycerol-3-phosphate phosphatase

See identical proteins and their annotated locations for NP_001162623.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

D3ZDK7

Conserved Domains (3) summary

TIGR01452
Location:28 → 315

PGP_euk; phosphoglycolate/pyridoxal phosphate phosphatase family

pfam13242
Location:232 → 315

Hydrolase_like; HAD-hyrolase-like

pfam13344
Location:31 → 139

Hydrolase_6; Haloacid dehalogenase-like hydrolase