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    P4ha2 prolyl 4-hydroxylase subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360526, updated on 27-Nov-2024

    Summary

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    Official Symbol
    P4ha2provided by RGD
    Official Full Name
    prolyl 4-hydroxylase subunit alpha 2provided by RGD
    Primary source
    RGD:1309673
    See related
    EnsemblRapid:ENSRNOG00000033663 AllianceGenome:RGD:1309673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to act upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in myopia. Orthologous to human P4HA2 (prolyl 4-hydroxylase subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 99.7), Heart (RPKM 98.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See P4ha2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38743894..38772741)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38243136..38271983)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39435227..39464134)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 4 Neighboring gene PDZ and LIM domain 4 Neighboring gene casein kinase 2 alpha 1, pseudogene 1 Neighboring gene colony stimulating factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. Helaakoski T, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753822, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procollagen-proline 4-dioxygenase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-2
    Names
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
    prolyl 4-hydroxylase, alpha polypeptide II
    NP_001101745.1
    NP_001386468.1
    NP_001386469.1
    NP_001386470.1
    NP_001386471.1
    NP_001386472.1
    XP_008765913.1
    XP_017452859.1
    XP_038942230.1
    XP_063125401.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108275.3 → NP_001101745.1  prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001101745.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ASK1, A6HEG7, A6HEG8
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. NM_001399539.1 → NP_001386468.1  prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ASK1, A6HEG7

    3. NM_001399540.1 → NP_001386469.1  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ACJ4

    4. NM_001399541.1 → NP_001386470.1  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ACJ4

    5. NM_001399542.1 → NP_001386471.1  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ACJ4

    6. NM_001399543.1 → NP_001386472.1  prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ACJ4
      Related
      ENSRNOP00000089755.1, ENSRNOT00000104075.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      38743894..38772741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767691.4 → XP_008765913.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_008765913.1

      UniProtKB/TrEMBL
      A0A8I6ASK1, A6HEG7, A6HEG8
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_039086302.2 → XP_038942230.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASK1, A6HEG7, A6HEG8
      Related
      ENSRNOP00000097385.1, ENSRNOT00000106136.2
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_063269331.1 → XP_063125401.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACJ4

    4. XM_017597370.3 → XP_017452859.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASK1, A6HEG7, A6HEG8
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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