Ddc dopa decarboxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddcprovided by RGD
Official Full Name: dopa decarboxylaseprovided by RGD
Primary source: RGD:2494
See related: EnsemblRapid:ENSRNOG00000004327 AllianceGenome:RGD:2494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AADC
Summary: Enables several functions, including amino acid binding activity; aromatic-L-amino-acid decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; dopamine biosynthetic process; and response to pyrethroid. Located in axon; neuronal cell body; and synaptic vesicle. Used to study Parkinson's disease. Biomarker of Parkinson's disease; end stage renal disease; nephrotic syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 88.8), Heart (RPKM 51.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (90592304..90682830, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (86378685..86469189, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (91905919..91996816, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.
Title: DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.
The data show that endothelial AADC plays an important role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent regulation of nitric oxide generation.
Title: Role of endothelial AADC in cardiac synthesis of serotonin and nitrates accumulation.
The expression of striatal L: -amino-acid decarboxylase (AADC) in L: -DOPA-induced dyskinesia rats, even though tyrosine hydroxylase (TH) expression did not increase.
Title: The roles of striatal serotonin and L -amino-acid decarboxylase on L-DOPA-induced Dyskinesia in a Hemiparkinsonian rat model.
AADC in the SCN is expressed in clock oscillating cells, and the decarboxylating activity of master clock cells are under the control of the circadian rhythm
Title: Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells.
1-methyl-4-phenylpyridinium caused rapid inhibition of DDC, which appears to result in intraneuronal accumulation and subsequent release of l-DOPA
Title: The parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) mediates release of l-3,4-dihydroxyphenylalanine (l-DOPA) and inhibition of l-DOPA decarboxylase in the rat striatum: a microdialysis study.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94401 (e-PCR)
- UniSTS:119649

RH130833 (e-PCR)
- UniSTS:214117

BF408245 (e-PCR)
- UniSTS:248753

RH143134 (e-PCR)
- UniSTS:232381

MARC_1879-1880:991931575:5 (e-PCR)
- UniSTS:230879

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5-hydroxy-L-tryptophan decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables 5-hydroxy-L-tryptophan decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables L-dopa decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables L-dopa decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables aromatic-L-amino-acid decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatic-L-amino-acid decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatic-L-amino-acid decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in catecholamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in dopamine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dopamine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in isoquinoline alkaloid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in phytoalexin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pyrethroid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in serotonin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aromatic-L-amino-acid decarboxylase

Names: L-Dopa decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase)

NP_001257781.1

EC 4.1.1.28

NP_001257782.1

EC 4.1.1.28

NP_036677.1

EC 4.1.1.28

XP_008768475.3

EC 4.1.1.28

XP_063128928.1

EC 4.1.1.28

XP_063128929.1

EC 4.1.1.28

XP_063128930.1

EC 4.1.1.28

XP_063128931.1

EC 4.1.1.28

XP_063128932.1

EC 4.1.1.28

XP_063128933.1

EC 4.1.1.28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270852.1 → NP_001257781.1 aromatic-L-amino-acid decarboxylase isoform a

See identical proteins and their annotated locations for NP_001257781.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).

Source sequence(s)

JAXUCZ010000014, M27716

UniProtKB/Swiss-Prot

P14173, Q6LEG4

UniProtKB/TrEMBL

A0A8L2QX98, A6KJB5

Related

ENSRNOP00000082788.1, ENSRNOT00000103628.2

Conserved Domains (1) summary

pfam00282
Location:35 → 414

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
NM_001270853.1 → NP_001257782.1 aromatic-L-amino-acid decarboxylase isoform b

See identical proteins and their annotated locations for NP_001257782.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.

Source sequence(s)

JAXUCZ010000014, JF273828, M27716

UniProtKB/TrEMBL

A0A8J8YSU9, D3ZMA5, F8TLS6

Related

ENSRNOP00000053885.5, ENSRNOT00000057051.6

Conserved Domains (1) summary

pfam00282
Location:35 → 374

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
NM_012545.4 → NP_036677.1 aromatic-L-amino-acid decarboxylase isoform a

See identical proteins and their annotated locations for NP_036677.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein (isoform a).

Source sequence(s)

JAXUCZ010000014, M27716

UniProtKB/Swiss-Prot

P14173, Q6LEG4

UniProtKB/TrEMBL

A0A8L2QX98, A6KJB5

Related

ENSRNOP00000005851.4, ENSRNOT00000005851.8

Conserved Domains (1) summary

pfam00282
Location:35 → 414

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

90592304..90682830 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272858.1 → XP_063128928.1 aromatic-L-amino-acid decarboxylase isoform X1

UniProtKB/TrEMBL

A0A8L2Q249
XM_008770253.4 → XP_008768475.3 aromatic-L-amino-acid decarboxylase isoform X5

UniProtKB/TrEMBL

A0A8I5ZZE6, D3ZMA5, F8TLS6

Related

ENSRNOP00000085523.1, ENSRNOT00000093904.2
XM_063272862.1 → XP_063128932.1 aromatic-L-amino-acid decarboxylase isoform X4

UniProtKB/Swiss-Prot

P14173, Q6LEG4

UniProtKB/TrEMBL

A0A8L2QX98, A6KJB5
XM_063272860.1 → XP_063128930.1 aromatic-L-amino-acid decarboxylase isoform X3

UniProtKB/TrEMBL

A0A8L2QX98
XM_063272861.1 → XP_063128931.1 aromatic-L-amino-acid decarboxylase isoform X3

UniProtKB/TrEMBL

A0A8L2QX98
XM_063272859.1 → XP_063128929.1 aromatic-L-amino-acid decarboxylase isoform X2

UniProtKB/TrEMBL

A0A8I5ZV89
XM_063272863.1 → XP_063128933.1 aromatic-L-amino-acid decarboxylase isoform X6

UniProtKB/TrEMBL

D3ZMA5, F8TLS6