Castor1 cytosolic arginine sensor for mTORC1 subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Castor1provided by RGD
Official Full Name: cytosolic arginine sensor for mTORC1 subunit 1provided by RGD
Primary source: RGD:1304774
See related: EnsemblRapid:ENSRNOG00000006740 AllianceGenome:RGD:1304774
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gatsl3; RGD1304774
Summary: Predicted to enable several functions, including arginine binding activity; identical protein binding activity; and protein sequestering activity. Predicted to be involved in cellular response to L-arginine; cellular response to amino acid starvation; and regulation of TORC1 signaling. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Orthologous to human CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 86.2), Lung (RPKM 51.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (83309710..83314123)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (79086136..79090549)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (84447552..84457396)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arginine binding	IBA Inferred from Biological aspect of Ancestor more info
enables arginine binding	ISO Inferred from Sequence Orthology more info
enables arginine binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular sensor activity	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to L-arginine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to L-arginine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-arginine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GATOR2 complex	ISO Inferred from Sequence Orthology more info
part_of GATOR2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytosolic arginine sensor for mTORC1 subunit 1

Names: GATS protein-like 3; GATS-like protein 3; Gats protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025128.1 → NP_001020299.1 cytosolic arginine sensor for mTORC1 subunit 1

See identical proteins and their annotated locations for NP_001020299.1

Status: PROVISIONAL

Source sequence(s)

BC091274

UniProtKB/Swiss-Prot

Q5BJZ0

UniProtKB/TrEMBL

A6IKF4

Related

ENSRNOP00000009150.4, ENSRNOT00000009150.8

Conserved Domains (2) summary

pfam13840
Location:257 → 321

ACT_7; ACT domain

pfam18700
Location:9 → 69

Castor1_N; Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain