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    Napg NSF attachment protein gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Napgprovided by RGD
    Official Full Name
    NSF attachment protein gammaprovided by RGD
    Primary source
    RGD:1310109
    See related
    EnsemblRapid:ENSRNOG00000018914 AllianceGenome:RGD:1310109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable soluble NSF attachment protein activity and syntaxin binding activity. Predicted to be involved in intracellular protein transport. Is active in synapse. Orthologous to human NAPG (NSF attachment protein gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 391.9), Kidney (RPKM 177.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Napg in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (58710702..58729450)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (56439620..56459159)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (58325319..58344071)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene APC down-regulated 1 Neighboring gene uncharacterized LOC134483041 Neighboring gene piezo-type mechanosensitive ion channel component 2 Neighboring gene transfer RNA alanine (anticodon GGC) 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distribution of soluble N-ethylmaleimide fusion protein attachment proteins (SNAPs) in the rat nervous system. Nishiki T, et al. Neuroscience, 2001. PMID 11718992
    2. Mapping of functional domains of gamma-SNAP. Tani K, et al. J Biol Chem, 2003 Apr 11. PMID 12554740
    3. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. Chen D, et al. J Biol Chem, 2001 Apr 20. PMID 11278501
    4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    5. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables soluble NSF attachment protein activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-soluble NSF attachment protein
    Names
    N-ethylmaleimide sensitive fusion protein attachment protein gamma
    N-ethylmaleimide-sensitive factor attachment protein, gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107384.2 → NP_001100854.1  gamma-soluble NSF attachment protein isoform 2

      See identical proteins and their annotated locations for NP_001100854.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IXL6, A6IXL7
      Conserved Domains (2) summary
      cd15832
      Location:29 → 64
      SNAP; TPR repeat [structural motif]
      cl24038
      Location:1 → 196
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    2. NM_001398659.1 → NP_001385588.1  gamma-soluble NSF attachment protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2K350, A6IXL2, A6IXL3
      Related
      ENSRNOP00000061787.3, ENSRNOT00000065802.4
      Conserved Domains (1) summary
      cd15832
      Location:8 → 278
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      58710702..58729450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096813.2 → XP_038952741.1  gamma-soluble NSF attachment protein isoform X1

      UniProtKB/TrEMBL
      A6IXL6, A6IXL7
      Conserved Domains (2) summary
      cd15832
      Location:29 → 64
      SNAP; TPR repeat [structural motif]
      cl24038
      Location:1 → 196
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    Nucleotide Protein Strain
    Heading Accession and Version

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