U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170920, updated on 27-Nov-2024

    Summary

    Official Symbol
    Map4k3provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 3provided by RGD
    Primary source
    RGD:621280
    See related
    EnsemblRapid:ENSRNOG00000007172 AllianceGenome:RGD:621280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to be active in cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 225.0), Lung (RPKM 194.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Map4k3 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20029246..20198583)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14276623..14446321)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (3276732..3444519, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479322 Neighboring gene uncharacterized LOC102551891 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene cyclin-dependent kinase-like 4 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 3
    Names
    GLK
    MAPK/ERK kinase kinase kinase 3
    MEK kinase kinase 3
    MEKKK 3
    germinal center kinase-related protein kinase
    NP_596898.1
    XP_006239718.2
    XP_017449508.2
    XP_017449509.2
    XP_017449510.2
    XP_038967654.1
    XP_038967655.1
    XP_038967656.1
    XP_038967657.1
    XP_038967658.1
    XP_038967659.1
    XP_038967660.1
    XP_038967661.1
    XP_063117574.1
    XP_063117575.1
    XP_063117576.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133407.1NP_596898.1  mitogen-activated protein kinase kinase kinase kinase 3

      See identical proteins and their annotated locations for NP_596898.1

      Status: VALIDATED

      Source sequence(s)
      AA819812, AF312224, AI502900, CK474868, DV716943
      UniProtKB/Swiss-Prot
      Q924I2
      UniProtKB/TrEMBL
      A6H9Q1, R9PXT4
      Conserved Domains (3) summary
      smart00036
      Location:540853
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:16273
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      20029246..20198583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111726.2XP_038967654.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AV17
      Conserved Domains (2) summary
      smart00036
      Location:583926
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    2. XM_039111728.2XP_038967656.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X4

      UniProtKB/TrEMBL
      R9PXT4
      Conserved Domains (2) summary
      smart00036
      Location:562905
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    3. XM_039111729.2XP_038967657.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AV17
      Conserved Domains (2) summary
      smart00036
      Location:583896
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    4. XM_039111727.2XP_038967655.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AV17
      Conserved Domains (2) summary
      smart00036
      Location:572915
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    5. XM_017594019.3XP_017449508.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AV17
      Conserved Domains (2) summary
      smart00036
      Location:572915
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    6. XM_017594021.3XP_017449510.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X7

      UniProtKB/TrEMBL
      R9PXT4
      Conserved Domains (2) summary
      smart00036
      Location:551894
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    7. XM_017594020.3XP_017449509.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AV17
      Related
      ENSRNOP00000090754.2, ENSRNOT00000110847.2
      Conserved Domains (2) summary
      smart00036
      Location:561904
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    8. XM_063261505.1XP_063117575.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X9

      Related
      ENSRNOP00000010366.8, ENSRNOT00000010366.9
    9. XM_063261504.1XP_063117574.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X8

      Related
      ENSRNOP00000069683.3, ENSRNOT00000084602.3
    10. XM_006239656.5XP_006239718.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JVZ8, A0A8I6AV17
      Related
      ENSRNOP00000097492.1, ENSRNOT00000118971.2
      Conserved Domains (2) summary
      smart00036
      Location:561874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    11. XM_039111730.2XP_038967658.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X11

      UniProtKB/TrEMBL
      R9PXT4
      Conserved Domains (2) summary
      smart00036
      Location:551864
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    12. XM_039111731.2XP_038967659.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JYP2
      Conserved Domains (2) summary
      smart00036
      Location:520863
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:1210
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    13. XM_039111732.1XP_038967660.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JYP2
      Conserved Domains (2) summary
      smart00036
      Location:494837
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1184
      PKc_like; Protein Kinases, catalytic domain
    14. XM_063261506.1XP_063117576.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X13

    15. XM_039111733.2XP_038967661.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JYP2
      Conserved Domains (2) summary
      smart00036
      Location:406749
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:196
      PKc_like; Protein Kinases, catalytic domain