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    Mrln myoregulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrlnprovided by RGD
    Official Full Name
    myoregulinprovided by RGD
    Primary source
    RGD:6490783
    See related
    EnsemblRapid:ENSRNOG00000069916 AllianceGenome:RGD:6490783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mln
    Summary
    Predicted to enable enzyme inhibitor activity. Predicted to act upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity; negative regulation of calcium ion import into sarcoplasmic reticulum; and response to wounding. Predicted to be located in sarcoplasmic reticulum membrane. Orthologous to human MRLN (myoregulin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 578.8) and Kidney (RPKM 25.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrln in Genome Data Viewer
    Location:
    20p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (18405858..18422874, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (18406789..18423805, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (19703628..19720596, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098837 Neighboring gene solute carrier family 16, member 9 Neighboring gene uncharacterized LOC102553246 Neighboring gene 40S ribosomal protein S26-like Neighboring gene coiled-coil domain containing 6 Neighboring gene ankyrin 3 Neighboring gene uncharacterized LOC102553944

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Anderson DM, et al. Cell, 2015 Feb 12. PMID 25640239, Free PMC Article
    2. Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Anderson DM, et al. Sci Signal, 2016 Dec 6. PMID 27923914, Free PMC Article
    3. Identification of candidate long non-coding RNAs in response to myocardial infarction. Zangrando J, et al. BMC Genomics, 2014 Jun 10. PMID 24917243, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of calcium ion import into sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of ATPase-coupled calcium transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of calcium ion import into sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myoregulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304741.1 → NP_001291670.1  myoregulin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6AUW5
      Related
      ENSRNOP00000083104.1, ENSRNOT00000097050.2
      Conserved Domains (1) summary
      cd20260
      Location:2 → 46
      Myoregulin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      18405858..18422874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601529.3 → XP_017457018.1  myoregulin isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUW5
      Conserved Domains (1) summary
      cd20260
      Location:2 → 46
      Myoregulin

    2. XM_017601528.3 → XP_017457017.1  myoregulin isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUW5
      Conserved Domains (1) summary
      cd20260
      Location:2 → 46
      Myoregulin
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.