Crip1 cysteine rich protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crip1provided by RGD
Official Full Name: cysteine rich protein 1provided by RGD
Primary source: RGD:1597237
See related: EnsemblRapid:ENSRNOG00000027990 AllianceGenome:RGD:1597237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Crip; Crp-1
Summary: Predicted to enable peptide binding activity and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to UV-B; intrinsic apoptotic signaling pathway in response to DNA damage; and prostate gland stromal morphogenesis. Predicted to be located in cytoplasm. Orthologous to human CRIP1 (cysteine rich protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 755.9), Thymus (RPKM 591.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (138047801..138055672)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (132226746..132234620)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (137959171..137967042)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

observed responses to overexpression of the CRIP gene are consistent with a role for this LIM protein in a cellular pathway that produces an imbalance in cytokine pattern favoring Th2 cytokines.
Title: Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133355 (e-PCR)
- UniSTS:216638

Crip (e-PCR), detects polymorphism
- UniSTS:141399

D6Wox21 (e-PCR)
- UniSTS:517785

D10Bir4 (e-PCR), detects polymorphism
- UniSTS:141484

RH127355 (e-PCR)
- UniSTS:210665

RH140839 (e-PCR)
- UniSTS:210665

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in cellular response to antibiotic	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in prostate gland stromal morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: cysteine-rich protein 1

Names: cysteine-rich intestinal protein; cysteine-rich protein 1 (intestinal)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134933.2 → NP_001128405.1 cysteine-rich protein 1

See identical proteins and their annotated locations for NP_001128405.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AI716760, CB729209

UniProtKB/Swiss-Prot

P63255

UniProtKB/TrEMBL

A6KBZ1

Related

ENSRNOP00000006835.3, ENSRNOT00000006835.7

Conserved Domains (1) summary

cd09478
Location:4 → 57

LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)
NM_001244867.1 → NP_001231796.1 cysteine-rich protein 1

See identical proteins and their annotated locations for NP_001231796.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AI716760, FQ223262

UniProtKB/Swiss-Prot

P63255

UniProtKB/TrEMBL

A6KBZ1

Conserved Domains (1) summary

cd09478
Location:4 → 57

LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)