Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chchd6provided by RGD
Official Full Name: coiled-coil-helix-coiled-coil-helix domain containing 6provided by RGD
Primary source: RGD:1304561
See related: EnsemblRapid:ENSRNOG00000060248 AllianceGenome:RGD:1304561
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in DNA damage response and cristae formation. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be part of MICOS complex. Predicted to be active in mitochondrion. Orthologous to human CHCHD6 (coiled-coil-helix-coiled-coil-helix domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 337.0), Brain (RPKM 103.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (123360729..123581429, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (121803501..122024209, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (121340952..121565222, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in cristae formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cristae formation	ISO Inferred from Sequence Orthology more info
involved_in cristae formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of MICOS complex	IEA Inferred from Electronic Annotation more info
part_of MICOS complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: MICOS complex subunit Mic25

Names: coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106608.1 → NP_001100078.1 MICOS complex subunit Mic25

See identical proteins and their annotated locations for NP_001100078.1

Status: PROVISIONAL

Source sequence(s)

CH473957

UniProtKB/Swiss-Prot

D4A7N1

UniProtKB/TrEMBL

A0A8I5ZNH1

Related

ENSRNOP00000073575.2, ENSRNOT00000088753.3

Conserved Domains (2) summary

pfam05300
Location:17 → 215

DUF737; Protein of unknown function (DUF737)

pfam06747
Location:223 → 256

CHCH; CHCH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

123360729..123581429 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107369.1 → XP_038963297.1 MICOS complex subunit Mic25 isoform X1

UniProtKB/TrEMBL

A0A8I5Y7K5, A0A8I5ZNH1

Related

ENSRNOP00000077240.1, ENSRNOT00000108353.2

Conserved Domains (2) summary

pfam05300
Location:22 → 186

DUF737; Protein of unknown function (DUF737)

pfam06747
Location:195 → 228

CHCH; CHCH domain
XM_039107371.2 → XP_038963299.1 MICOS complex subunit Mic25 isoform X3

Conserved Domains (2) summary

pfam05300
Location:55 → 104

DUF737; Protein of unknown function (DUF737)

pfam06747
Location:113 → 146

CHCH; CHCH domain
XM_063285819.1 → XP_063141889.1 MICOS complex subunit Mic25 isoform X2