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    Art3 ADP-ribosyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art3provided by RGD
    Official Full Name
    ADP-ribosyltransferase 3provided by RGD
    Primary source
    RGD:628833
    See related
    EnsemblRapid:ENSRNOG00000002256 AllianceGenome:RGD:628833
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be located in membrane. Orthologous to human ART3 (ADP-ribosyltransferase 3 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1090.7), Muscle (RPKM 1061.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Art3 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (15921540..16003764, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (15637230..15719442, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17143037..17225389, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene scavenger receptor class B, member 2 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene nucleoporin 54 Neighboring gene CWF19 like cell cycle control factor 1, pseudogene 1 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene SDA1 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury. Shi W, et al. J Mol Histol, 2012 Feb. PMID 22037978
    2. ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. Wang B, et al. J Biol Chem, 1997 Jul 11. PMID 9211900
    3. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. Koch-Nolte F, et al. Genomics, 1997 Feb 1. PMID 9119374
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ART3 may play important roles in CNS pathophysiology after traumatic brain injury (TBI).
      Title: The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ecto-ADP-ribosyltransferase 3
    NP_001012034.1
    XP_006250789.3
    XP_006250790.2
    XP_038947782.1
    XP_038947783.1
    XP_038947784.1
    XP_038947785.1
    XP_038947786.1
    XP_063129126.1
    XP_063129127.1
    XP_063129128.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012034.1 → NP_001012034.1  ecto-ADP-ribosyltransferase 3 precursor

      See identical proteins and their annotated locations for NP_001012034.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079018
      UniProtKB/TrEMBL
      A0A8I6GLM8, Q6AYJ9
      Related
      ENSRNOP00000096536.3, ENSRNOT00000104054.3
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      15921540..16003764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091856.2 → XP_038947784.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLM8
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    2. XM_039091857.2 → XP_038947785.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLM8
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    3. XM_006250727.4 → XP_006250789.3  ecto-ADP-ribosyltransferase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A9H4, A0A8I6GLM8
      Related
      ENSRNOP00000088287.3, ENSRNOT00000119410.3

    4. XM_006250728.4 → XP_006250790.2  ecto-ADP-ribosyltransferase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GLM8, F7EXX0
      Related
      ENSRNOP00000095609.2, ENSRNOT00000117638.3

    5. XM_039091854.2 → XP_038947782.1  ecto-ADP-ribosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLM8
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    6. XM_063273056.1 → XP_063129126.1  ecto-ADP-ribosyltransferase 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K8S9, A0A8I6GLM8
      Related
      ENSRNOP00000074723.4, ENSRNOT00000085525.4

    7. XM_039091855.2 → XP_038947783.1  ecto-ADP-ribosyltransferase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLM8
      Conserved Domains (1) summary
      cl00173
      Location:46 → 268
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    8. XM_063273058.1 → XP_063129128.1  ecto-ADP-ribosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      A6KK90

    9. XM_063273057.1 → XP_063129127.1  ecto-ADP-ribosyltransferase 3 isoform X6

      UniProtKB/TrEMBL
      A6KK90

    10. XM_039091858.2 → XP_038947786.1  ecto-ADP-ribosyltransferase 3 isoform X8

      UniProtKB/TrEMBL
      A6KK90
      Conserved Domains (1) summary
      cl00173
      Location:29 → 251
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
    Nucleotide Protein Strain
    Heading Accession and Version

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